CARD10 Antibody

Code CSB-PA871592ESR2HU
Size US$166
  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA871592ESR2HU at dilution of 1:100

  • Immunofluorescent analysis of A549 cells using CSB-PA871592ESR2HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CARD10 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
Bcl10 binding protein and activator of NFKB antibody; BIMP1 antibody; CAR10_HUMAN antibody; CARD 10 antibody; CARD containing MAGUK 3 protein antibody; CARD-containing MAGUK 3 antibody; CARD-containing MAGUK protein 3 antibody; CARD10 antibody; Carma 3 antibody; CARMA3 antibody; Caspase Recruitment Domain family member 10 antibody; Caspase recruitment domain-containing protein 10 antibody
Raised in
Species Reactivity
Recombinant Human Caspase recruitment domain-containing protein 10 protein (863-1032AA)
Immunogen Species
Homo sapiens (Human)
Purification Method
Antigen Affinity Purified
It differs from different batches. Please contact us to confirm it.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Tested Applications
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Activates NF-kappa-B via BCL10 and IKK.
Gene References into Functions
  1. The results suggest that the involvement of CARMA3 in DNA damage-induced NF-kappaB is through the recruitment of TRAF6. PMID: 28717989
  2. Card10 polymorphisms may not be linked with psoriasis vulgaris in the southern Han Chinese population. PMID: 28301668
  3. Data indicate no association between caspase recruitment domain family, member 10 protein (CARD10) polymorphism rs6000782 and type 1 autoimmune hepatitis (AIH) in a Japanese population. PMID: 26652023
  4. Findings indicate that CARMA3 may suppress the activation of the P38 MAPK signaling pathway to regulate invasion, migration and apoptosis of lung cancer cells by activating NF-small ka, CyrillicB (P65) in the nucleus. PMID: 26526492
  5. miR-24 inhibited cell proliferation, invasion and epithelial to mesenchymal transition in bladder cancer cells by downregulation of CARMA3 PMID: 26252200
  6. The study identified the DEP domain-containing protein DEPDC7 as cellular binding partner of CARMA2 and CARMA3 proteins. PMID: 25541973
  7. A novel mechanism of CARMA3 in lung cancer stemness and metastasis through the negative regulation of NME2 was identified. PMID: 25906011
  8. CARMA3 regulates the ovarian cancer cell proliferation, cell cycle progression, and chemoresistance. PMID: 24833094
  9. CARMA3 is overexpressed in pancreatic cancer and regulates malignant cell growth, invasion, and NF-kappaB signaling, which was dependent on its association with Bcl10. PMID: 24633921
  10. CARMA3 is overexpressed in bladder cancer and regulates malignant cell growth and NF-kappaB signaling. PMID: 24443255
  11. Genetic variation within PARP1 and CARD10 was associated with rate of hippocampal neurodegeneration in APOE e3/e3 patients. PMID: 23608917
  12. CARD10 may be involved in hepatic carcinogenesis associated with hepatitis C in Egyptian patients. PMID: 24018495
  13. overexpression of CARMA3 in human glioma and its correlation with tumor grade. PMID: 23893382
  14. Data show that CARMA3 may serve as a novel and prognostic marker for renal cell carcinoma (RCC) and play a role during the development and progression of the disease. PMID: 23771851
  15. CARMA3 facilitates proliferation and inhibits apoptosis through nuclear factor-kappaB signaling. PMID: 23708960
  16. this study found that CARMA3 is overexpressed in colon cancers and contributes to malignant cell growth by facilitating cell cycle progression through NF-kappaB mediated upregulation of cyclin D1. PMID: 22884800
  17. The overexpression of CARMA3 was significantly correlated with TNM stage (P = 0.022) and tumor status (P = 0.013). PMID: 22615840
  18. Polymorphisms of ATOH7, TGFBR3 and CARD10 influence the size of optic disc area. PMID: 21307088
  19. Data show that CARMA3 and Bcl10 contributed to several characteristics of EGFR-associated malignancy, including proliferation, survival, migration, and invasion. PMID: 21406399
  20. CARMA1 and CARMA3 bind to Ikappa kinase gamma-NFkappaB in B and T lymphocytes PMID: 15184390
  21. Protein kinase C-CARMA3 signaling axis plays an essential role in lysophosphatidic acid-induced ovarian cancer cell in vitro invasion. PMID: 17724468
  22. results further define the molecular mechanisms that control activation of NF-kappaB and reveal a function for A20 in the regulation of CARMA and BCL10 activity in lymphoid and non-lymphoid cells PMID: 18349075
  23. Data demonstrate that lysophosphatidic acid stimulates thymic stromal lymphopoietin and CCL20 expression in bronchial epithelial cells via CARMA3-mediated NF-kappaB activation. PMID: 18757306

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Subcellular Location
Tissue Specificity
Detected in adult heart, kidney and liver; lower levels in intestine, placenta, muscle and lung. Also found in fetal lung, liver and kidney.
Database Links

HGNC: 16422

OMIM: 607209

KEGG: hsa:29775

STRING: 9606.ENSP00000251973

UniGene: Hs.57973

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