CDK13 Antibody

Datasheet

Code	CSB-PA613482LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA613482LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CDK13 Polyclonal antibody

Uniprot No.

Q14004

Target Names

CDK13

Alternative Names

CDC2 related protein kinase 5 antibody; CDC2-related protein kinase 5 antibody; CDC2L antibody; CDK13 antibody; CDK13_HUMAN antibody; cell division controller cholinesterase related antibody; cell division cycle 2 like 5 (cholinesterase related cell division controller) antibody; cell division cycle 2 like 5 antibody; Cell division cycle 2 like protein kinase 5 antibody; Cell division cycle 2-like protein kinase 5 antibody; Cell division protein kinase 13 antibody; CHED antibody; Cholinesterase related cell division controller antibody; Cholinesterase-related cell division controller antibody; cyclin dependent kinase 13 antibody; Cyclin-dependent kinase 13 antibody; hCDK13 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Cyclin-dependent kinase 13 protein (1-170AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CDK13 Antibody (Product code: CSB-PA613482LA01HU) is Non-conjugated. For CDK13 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA613482LB01HU	CDK13 Antibody, HRP conjugated	ELISA
FITC	CSB-PA613482LC01HU	CDK13 Antibody, FITC conjugated
Biotin	CSB-PA613482LD01HU	CDK13 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef.

Gene References into Functions

Heterozygous constitutional CDK13 mutations in 3 patients cause intellectual disability without cardiac defects. PMID: 29222009
CDK13 RNA over-editing sites mediated by ADAR1 may serve as novel cancer driver events in HCC progression. PMID: 29996118
heterozygous, likely dominant negative mutations affecting the protein kinase domain of the CDK13 gene result in a recognisable, syndromic form of intellectual disability, with or without congenital heart disease. PMID: 29021403
Mutation in CHK13 gene is associated with congenital heart defects. PMID: 27479907
Detailed phenotypic and molecular characterisation of 9 individuals with pathogenic variants in CDK13 is provided. Two individuals had novel CDK13 variants (p.Asn842Asp, p.Lys734Glu), while the remaining seven unrelated individuals had a recurrent, previously published p.Asn842Ser variant. PMID: 28807008
CDK13 gene is amplified in different types of cancer indicate that this kinase can contribute to cancer development in human. PMID: 26886422
CDK12 and CDK13 losses in HCT116 cells preferentially affect expression of DNA damage response. PMID: 25561469
High CDK13 expression is associated with pancreatic cancer. PMID: 25216700
Coincidently amplified CDK13, GMNN, and CENPF genes can play a role as common cancer-driver genes in human cancers. PMID: 22912832
CDK13 interacts with cyclin K, and is required for self-renewal in ES cells. PMID: 22547058
Data demonstrate that CDC2L5 is located in the nucleoplasm, where it directly interacts with the ASF/SF2-associated protein p32, a protein involved in splicing regulation. PMID: 16721827

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Involvement in disease

Congenital heart defects, dysmorphic facial features, and intellectual developmental disorder (CHDFIDD)

Subcellular Location

Nucleus speckle.

Protein Families

Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily

Tissue Specificity

Expressed in fetal brain, liver, muscle and in adult brain. Also expressed in neuroblastoma and glioblastoma tumors.

Database Links

HGNC: 1733

OMIM: 603309

KEGG: hsa:8621

STRING: 9606.ENSP00000181839

UniGene: Hs.233552

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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