CELF4 Antibody

Code CSB-PA883643LA01HU
Size US$166
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Image
  • IHC image of CSB-PA883643LA01HU diluted at 1:200 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CELF4 Polyclonal antibody
Uniprot No.
Target Names
CELF4
Alternative Names
CELF4 antibody; BRUNOL4 antibody; CUGBP Elav-like family member 4 antibody; CELF-4 antibody; Bruno-like protein 4 antibody; CUG-BP- and ETR-3-like factor 4 antibody; RNA-binding protein BRUNOL-4 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human CUGBP Elav-like family member 4 protein (120-236AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The CELF4 Antibody (Product code: CSB-PA883643LA01HU) is Non-conjugated. For CELF4 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA883643LB01HU CELF4 Antibody, HRP conjugated ELISA
FITC CSB-PA883643LC01HU CELF4 Antibody, FITC conjugated
Biotin CSB-PA883643LD01HU CELF4 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:200-1:500
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.
Gene References into Functions
  1. The present study refines the molecular and neuropsychiatric phenotype associated with 18q12.2 deletion leading to CELF4 haploinsufficiency and provides evidence for a role for CELF4 in brain development and autism spectrum disorders. PMID: 28407444
  2. Authors report a modifying effect of a polymorphism of CELF4 on the dose-dependent association between anthracyclines and cardiomyopathy, which possibly occurs through a pathway that involves the expression of abnormally spliced TNNT2 variants. PMID: 26811534
  3. Determination of CELF4 protein domains required for RNA splicing. PMID: 14973222
  4. validated occurrence of an unusual TG 3' splice site in intron 6 PMID: 17672918
Subcellular Location
Nucleus. Cytoplasm.
Protein Families
CELF/BRUNOL family
Tissue Specificity
Ubiquitous. Strongly expressed in the cerebellum, hippocampus, amygdala, temporal and frontal cortex and frontal lobes.
Database Links

HGNC: 14015

OMIM: 612679

KEGG: hsa:56853

STRING: 9606.ENSP00000355089

UniGene: Hs.435976

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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