CELF4 Antibody

Datasheet

Code	CSB-PA883643LA01HU
Size	US$166
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Image	IHC image of CSB-PA883643LA01HU diluted at 1:200 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CELF4 Polyclonal antibody

Uniprot No.

Q9BZC1

Target Names

CELF4

Alternative Names

CELF4 antibody; BRUNOL4 antibody; CUGBP Elav-like family member 4 antibody; CELF-4 antibody; Bruno-like protein 4 antibody; CUG-BP- and ETR-3-like factor 4 antibody; RNA-binding protein BRUNOL-4 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human CUGBP Elav-like family member 4 protein (120-236AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CELF4 Antibody (Product code: CSB-PA883643LA01HU) is Non-conjugated. For CELF4 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA883643LB01HU	CELF4 Antibody, HRP conjugated	ELISA
FITC	CSB-PA883643LC01HU	CELF4 Antibody, FITC conjugated
Biotin	CSB-PA883643LD01HU	CELF4 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:200-1:500

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.

Gene References into Functions

The present study refines the molecular and neuropsychiatric phenotype associated with 18q12.2 deletion leading to CELF4 haploinsufficiency and provides evidence for a role for CELF4 in brain development and autism spectrum disorders. PMID: 28407444
Authors report a modifying effect of a polymorphism of CELF4 on the dose-dependent association between anthracyclines and cardiomyopathy, which possibly occurs through a pathway that involves the expression of abnormally spliced TNNT2 variants. PMID: 26811534
Determination of CELF4 protein domains required for RNA splicing. PMID: 14973222
validated occurrence of an unusual TG 3' splice site in intron 6 PMID: 17672918

Subcellular Location

Nucleus. Cytoplasm.

Protein Families

CELF/BRUNOL family

Tissue Specificity

Ubiquitous. Strongly expressed in the cerebellum, hippocampus, amygdala, temporal and frontal cortex and frontal lobes.

Database Links

HGNC: 14015

OMIM: 612679

KEGG: hsa:56853

STRING: 9606.ENSP00000355089

UniGene: Hs.435976

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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