CEP120 Antibody

Datasheet

Code	CSB-PA836696ESR2HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA836696ESR2HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA836696ESR2HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CEP120 Polyclonal antibody

Uniprot No.

Q8N960

Target Names

CEP120

Alternative Names

CCDC100 antibody; CE120_HUMAN antibody; Centrosomal protein of 120 kDa antibody; Cep120 antibody; Coiled-coil domain-containing protein 100 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Centrosomal protein of 120 kDa protein (1-270AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. Required for centriole duplication and maturation during mitosis and subsequent ciliogenesis. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner.

Gene References into Functions

The CEP120-associated phenotype ranges from mild classical JS in four patients to more severe conditions in two fetuses. PMID: 27208211
We establish a novel locus for Jeune asphyxiating thoracic dystrophy on 5q23.2 by linkage analysis and demonstrate that a mutation in CEP120 within this locus is the most likely cause of the disease. PMID: 25361962
Functional characterization of the homologous mouse gene, and comparison to the human protein. PMID: 17920017

Involvement in disease

Short-rib thoracic dysplasia 13 with or without polydactyly (SRTD13); Joubert syndrome 31 (JBTS31)

Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Protein Families

CEP120 family

Database Links

HGNC: 26690

OMIM: 613446

KEGG: hsa:153241

STRING: 9606.ENSP00000303058

UniGene: Hs.483209

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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