CEP164 Antibody

Datasheet

Code	CSB-PA892491LA01HU
Size	US$166
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Image	IHC image of CSB-PA892491LA01HU diluted at 1:600 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CEP164 Polyclonal antibody

Uniprot No.

Q9UPV0

Target Names

CEP164

Alternative Names

AI450905 antibody; BC027092 antibody; CE164_HUMAN antibody; Centrosomal protein 164 antibody; Centrosomal protein 164kDa antibody; Centrosomal protein of 164 kDa antibody; Cep164 antibody; D030051D21 antibody; FLJ54767 antibody; KIAA1052 antibody; MGC38792 antibody; mKIAA1052 antibody; NPHP15 antibody; OTTMUSP00000042044 antibody; RGD1560988 antibody; RGD1561243 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Centrosomal protein of 164 kDa protein (1-112AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CEP164 Antibody (Product code: CSB-PA892491LA01HU) is Non-conjugated. For CEP164 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA892491LB01HU	CEP164 Antibody, HRP conjugated	ELISA
FITC	CSB-PA892491LC01HU	CEP164 Antibody, FITC conjugated
Biotin	CSB-PA892491LD01HU	CEP164 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:500-1:1000

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1.

Gene References into Functions

data suggest that CEP164 is not required in the DNA damage response. PMID: 26966185
This study reveals a novel role for CEP164 in the pathogenesis of nephronophthisis, in which mutations cause ciliary defects coupled with DNA damage induced replicative stress, cell death, and epithelial-to-mesenchymal transition PMID: 25340510
Evidence is provided that TTBK2 effectively phosphorylate Cep164 and Cep97 and inhibits the interaction between Cep164 and its binding partner Dishevelled-3 (an important regulator of ciliogenesis) in a kinase activity-dependent manner. PMID: 25297623
data suggest that TTBK2 also acts upstream of Cep164, contributing to the assembly of distal appendages PMID: 24982133
Cep164 is targeted to the apical domain of the mother centriole to provide the molecular link between the mother centriole and the membrane biogenesis machinery that initiates cilia formation. PMID: 23253480
findings indicate that ARL13B, INPP5E, PDE6D, and CEP164 form a distinct functional network that is involved in JBTS and NPHP but independent of the ones previously defined by NPHP and MKS proteins PMID: 23150559
Study identifies by whole-exome resequencing, mutations of MRE11, ZNF423, and CEP164 as causing Nephronophthisis-related ciliopathies. PMID: 22863007
Single nucleotide polymorphisms of CCND2, RAD23B, GRP78, CEP164, MDM2, and ALDH2 genes were significantly associated with development and recurrence of hepatocellular carcinoma in Japanese patients with hepatitis C virus. PMID: 22004425
These data implicate distal appendages in primary cilia formation and identify Cep164 as an excellent marker for these structures. PMID: 17954613
Cep164 is a key player in the DNA damage-activated signaling cascade. PMID: 18283122
Results show that Cep164 knockdown compromises the cell survival upon UV damage, and that UV irradiation significantly enhances the interaction between Cep164 and XPA. PMID: 19197159

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Involvement in disease

Nephronophthisis 15 (NPHP15)

Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus.

Tissue Specificity

Expressed in several cell lines.

Database Links

HGNC: 29182

OMIM: 614845

KEGG: hsa:22897

STRING: 9606.ENSP00000278935

UniGene: Hs.504009

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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