CEP41 Antibody

Code CSB-PA080028
Size US$100
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Product Details

Uniprot No.
Target Names
CEP41
Alternative Names
centrosomal protein 41 kDa antibody; Centrosomal protein of 41 kDa antibody; CEP 41 antibody; Cep41 antibody; CEP41_HUMAN antibody; testis specific 14 antibody; testis specific gene A14 antibody; Testis specific gene A14 protein antibody; testis specific protein A14 antibody; Testis-specific gene A14 protein antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from the Internal region of Human CEP41.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
IHC, ELISA
Recommended Dilution
Application Recommended Dilution
IHC 1:100-1:300
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium.
Gene References into Functions
  1. In cortices, the MEST promoter was hemimethylated, as expected for a differentially methylated imprinting control region, whereas the COPG2 and TSGA14 promoters were completely demethylated, typical for transcriptionally active non-imprinted genes. PMID: 22456293
  2. The data identified CEP41 mutations as a cause of Joubert syndrome and implicated tubulin post-translational modification in the pathogenesis of human ciliary dysfunction. PMID: 22246503
  3. Three rare potentially pathogenic variants were identified in the TSGA14 gene, which encodes a centrosomal protein. PMID: 21438139
Involvement in disease
Joubert syndrome 15 (JBTS15)
Subcellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes mainly to the cilium basal body and in primary cilia.
Protein Families
CEP41 family
Tissue Specificity
[Isoform 1]: Expressed in testis and fetal tissues.; [Isoform 3]: Expressed in testis and fetal tissues.
Database Links

HGNC: 12370

OMIM: 610523

KEGG: hsa:95681

STRING: 9606.ENSP00000223208

UniGene: Hs.368315

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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