CHD5 Antibody

1. CHD5 was identified as a direct target of miR-454. CHD5 was downregulated in GC tissues/cell lines and the expresssion of CHD5 inversely correlated with the level of miR-454 in GC tissues. Taken together, these observations indicate that HDAC3 is associated with GC cell growth via the miR-454-mediated targeting of CHD5. PMID: 29115379
2. Data show that chromodomain helicase DNA binding protein 5 (CHD5) acted as a functional tumor suppressor and was frequently silenced by promoter CpG methylation in renal cell carcinoma (RCC). PMID: 26943038
3. CHD5 may act as a tumor suppressor gene in NSCLC. PMID: 28400267
4. Authors identified the CHD5 as a direct target of miR-454. CHD5 was downregulated in HCC tissues and cell lines and the expression level of CHD5 was inversely correlated with the expression of miR-454 in HCC tissues. PMID: 26287602
5. Data show a mutual suppression regulation between chromodomain helicase DNA binding protein 5 (CHD5) and enhancer of zeste homolog 2 (EZH2, which may provide new insights into their potential therapeutic significance for hepatocellular carcinoma (HCC). PMID: 26517514
6. CHD5 methylation of rectal cancer has a great effect in influencing its clinical and pathological features. PMID: 26753653
7. Study shows that CHD5 is a Nucleosome remodeling and deacetylase complex-associated transcriptional repressor and identifies WEE1 as one of the CHD5-regulated genes that may link CHD5 to tumor suppression. PMID: 25247294
8. Low CHD5 expression activates the DNA damage response and predicts poor outcome in patients undergoing adjuvant therapy for resected pancreatic cancer. PMID: 24276239
9. CHD5 is a potential tumour suppressor gene epigenetically silenced in hepatocellular carcinoma. PMID: 24529164
10. The tumor suppressor chromodomain helicase DNA-binding protein 5 (CHD5) remodels nucleosomes by unwrapping. PMID: 24923445
11. repression of CHD5 gene expression in human leukemia is mediated in part by DNA methylation of its promoter. PMID: 24454811
12. CHD5 activity is regulated by DNA methylation and repressive histone modifications. CHD5 likely acts as a tumor-suppressor gene in early colorectal carcinogenesis. PMID: 24243398
13. CHD5 might act as a tumor suppressor in glioma PMID: 23707602
14. These findings provide insights into the regulatory role of CHD5 during neurogenesis and suggest how inactivation of this candidate tumor suppressor might contribute to neuroblastoma. PMID: 23948251
15. Decreased expression of chromodomain helicase DNA-binding protein 5 is associated with primary gallbladder carcinoma PMID: 22855185
16. CHD% protein mediates the p53-dependent senescence program triggered by decreased JMJD2A levels. PMID: 23168260
17. study concludes that down-regulation of CHD5, mediated at least in part by promoter methylation, contributes to the development and progression of human breast cancer PMID: 22569290
18. In this Caucasian population, endometriosis seems to be associated with the tumor-suppressor gene CHD5. Our findings support recent data, suggesting that the 1p36 region plays an important role in endometrios. PMID: 22910690
19. CHD5 is a potential tumor suppressor gene that is inactivated via an epigenetic mechanism in lung cancer. PMID: 22186629
20. Studies identified three genes, CHD5, PAFAH1B1, and NME1, strongly associated with patient outcome. PMID: 22328561
21. We conclude that (i) somatically acquired CHD5 mutations are rare in primary NBs, so inactivation probably occurs by deletion and epigenetic silencing. PMID: 22294723
22. the association of between miR-211-regulated CHD5 expression and CHD5 function in colorectal tumorigenesis PMID: 22235338
23. CHD5 is downregulated in a certain number of ovarian cancers and appears to be an adverse predictor candidate of ovarian cancer disease-free and total survival. PMID: 21860208
24. data suggest that CHD5 is a tumor suppressor gene that is epigenetically downregulated in laryngeal squamous cell carcinoma. PMID: 21636313
25. As only one of the 47 families studied has the CHD5 rs7513548 SNP variant, it appears to be a rare event and further screening of melanoma families is required to confirm whether or not CHD5 is involved in melanoma pathogenesis. PMID: 21250965
26. Data show a strong association of CHD5 expression with favorable prognostic variables (age at diagnosis <12 months, low clinical stage, and favorable histology), overall survival and event-free survival. PMID: 20950435
27. CHD5 is a tumor suppressor gene epigenetically down-regulated in gastric cancer PMID: 19840376
28. CDH5 may play a role in the development of the nervous system, and it may also play a role in the pathogenesis of neural tumors. PMID: 12592387
29. Study demonstrates that Chd5 functions as a tumor suppressor in vivo and implicates deletion of CHD5 in human cancer. PMID: 17289567
30. A recent functional study identified chromodomain helicase DNA-binding protein 5 (CHD5) as a novel tumor suppressor mapping to 1p36. [REVIEW] PMID: 18413720
31. CHD5 is the strongest candidate tumor suppressor gene that is deleted from 1p36.31 in neuroblastomas, and inactivation of the second allele may occur by an epigenetic mechanism. PMID: 18577749
32. the DNA methylation profiles of CHD family members (CHD1-9) in different tumor types. PMID: 18698156
33. study demonstrated the existence of somatic mutations and methylation of CHD5 in primary epithelial ovarian cancers; CHD5 may play a role as a tumor suppressor gene in ovarian cancer PMID: 18953434

Show More

Hide All

HGNC: 16816

OMIM: 610771

KEGG: hsa:26038

STRING: 9606.ENSP00000262450

UniGene: Hs.522898