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Your Good Partner in Biology Research
| Code | CSB-PA881032LD01HU |
| Size | US$299 |
| Full Product Name | Rabbit anti-Homo sapiens (Human) CHMP1A Polyclonal antibody |
| Uniprot No. | Q9HD42 |
| Target Names | CHMP1A |
| Alternative Names | Charged multivesicular body protein 1a (Chromatin-modifying protein 1a) (CHMP1a) (Vacuolar protein sorting-associated protein 46-1) (Vps46-1) (hVps46-1), CHMP1A, CHMP1 KIAA0047 PCOLN3 PRSM1 |
| Raised in | Rabbit |
| Species Reactivity | Human |
| Immunogen | Recombinant Human Charged multivesicular body protein 1a protein (1-196AA) |
| Immunogen Species | Homo sapiens (Human) |
| Conjugate | Biotin |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification Method | >95%, Protein G purified |
| Concentration | It differs from different batches. Please contact us to confirm it. |
| Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Form | Liquid |
| Tested Applications | ELISA |
| Protocols | ELISA Protocol |
| Troubleshooting and FAQs | Antibody FAQs |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Lead Time | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time. |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Function | Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing. |
| Involvement in disease | Pontocerebellar hypoplasia 8 (PCH8) |
| Subcellular Location | Cytoplasm, Endosome membrane, Peripheral membrane protein, Nucleus matrix |
| Protein Families | SNF7 family |
| Tissue Specificity | Expressed in placenta, cultured skin fibroblasts and in osteoblast cell line MG-63. |
| Database Links |
HGNC: 8740 OMIM: 164010 KEGG: hsa:5119 STRING: 9606.ENSP00000380998 UniGene: Hs.589427 |
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