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| Code | CSB-PA881032LD01HU |
| Size | US$299 |
| Uniprot No. | Q9HD42 |
| Protocols | ELISA Protocol |
| Immunogen | Recombinant Human Charged multivesicular body protein 1a protein (1-196AA) |
| Raised in | Rabbit |
| Species Reactivity | Human |
| Tested Applications | ELISA |
| Relevance | Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing. |
| Form | Liquid |
| Conjugate | Biotin |
| Storage Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method | >95%, Protein G purified |
| Isotype | IgG |
| Clonality | Polyclonal |
| Alias | Charged multivesicular body protein 1a (Chromatin-modifying protein 1a) (CHMP1a) (Vacuolar protein sorting-associated protein 46-1) (Vps46-1) (hVps46-1), CHMP1A, CHMP1 KIAA0047 PCOLN3 PRSM1 |
| Immunogen Species | Homo sapiens (Human) |
| Research Area | Cell Biology |
| Target Names | CHMP1A |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
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| Function | Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing. |
| Involvement in disease | Pontocerebellar hypoplasia 8 (PCH8) |
| Subcellular Location | Cytoplasm, Endosome membrane, Peripheral membrane protein, Nucleus matrix |
| Protein Families | SNF7 family |
| Tissue Specificity | Expressed in placenta, cultured skin fibroblasts and in osteoblast cell line MG-63. |
| Database Links |
HGNC: 8740 OMIM: 164010 KEGG: hsa:5119 STRING: 9606.ENSP00000380998 UniGene: Hs.589427 |
| Pathway |
Necroptosis
Endocytosis |
CHMP1A Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA005358GA01HU | CHMP1A Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA116460 | CHMP1A Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA903339 | CHMP1A Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA881032LB01HU | CHMP1A Antibody, HRP conjugated | Human | ELISA |
| CSB-PA881032LC01HU | CHMP1A Antibody, FITC conjugated | Human | ELISA |
CHMP1A Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA881032LA01HU | CHMP1A Antibody | Human | ELISA, WB, IHC, IF |
CHMP1A Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP881032HU CSB-EP881032HU CSB-BP881032HU CSB-MP881032HU |
Recombinant Human Charged multivesicular body protein 1a(CHMP1A) | Yeast E.coli Baculovirus Mammalian cell |
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Species Reactivity: Human
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Species Reactivity: Human
