CHSY1 Antibody, Biotin conjugated

Datasheet
Code CSB-PA005416LD01HU
Size US$299
Uniprot No. Q86X52
Protocols ELISA Protocol
Immunogen Recombinant Human Chondroitin sulfate synthase 1 protein (32-148AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Involved in the negative control of osteogenesis likely through the modulation of NOTCH signaling.
Form Liquid
Conjugate Biotin
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Chondroitin sulfate synthase 1 (EC 2.4.1.175) (EC 2.4.1.226) (Chondroitin glucuronyltransferase 1) (Chondroitin synthase 1) (ChSy-1) (Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase 1) (N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1) (N-acetylgalactosaminyltransferase 1), CHSY1, CHSY CSS1 KIAA0990
Immunogen Species Homo sapiens (Human)
Research Area Tags & Cell Markers
Target Names CHSY1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Involved in the negative control of osteogenesis likely through the modulation of NOTCH signaling.
Involvement in disease Temtamy preaxial brachydactyly syndrome (TPBS)
Subcellular Location Golgi apparatus, Golgi stack membrane, Single-pass type II membrane protein, Secreted
Protein Families Chondroitin N-acetylgalactosaminyltransferase family
Tissue Specificity Ubiquitous, with the highest levels in placenta. Detected at low levels in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, adrenal gland, mammary gland, stomach, small intestine, lung and peripheral blood leukocytes.
Database Links

HGNC: 17198

OMIM: 605282

KEGG: hsa:22856

STRING: 9606.ENSP00000254190

UniGene: Hs.110488

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