CIART Antibody

Code CSB-PA850790LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA850790LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CIART Polyclonal antibody
Uniprot No.
Target Names
CIART
Alternative Names
CIART antibody; C1orf51Circadian-associated transcriptional repressor antibody; ChIP-derived repressor of network oscillator antibody; Chrono antibody; Computationally highlighted repressor of the network oscillator antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Circadian-associated transcriptional repressor protein (1-385AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The CIART Antibody (Product code: CSB-PA850790LA01HU) is Non-conjugated. For CIART Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA850790LB01HU CIART Antibody, HRP conjugated ELISA
FITC CSB-PA850790LC01HU CIART Antibody, FITC conjugated
Biotin CSB-PA850790LD01HU CIART Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5'-CACGTG-3') on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response.
Gene References into Functions
  1. Study shows that:1- Chrono is a circadian clock gene whose transcription exhibits a robust circadian oscillation. 2- Is is a repressor of circadian transcriptional/translational feedback loops. 3- It may function to link epigenetic control mechanisms to stress responses. [review] PMID: 28010116
Subcellular Location
Nucleus. Nucleus, PML body.
Database Links

HGNC: 25200

OMIM: 615782

KEGG: hsa:148523

STRING: 9606.ENSP00000290363

UniGene: Hs.54680

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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