CLDND1 Antibody

Code CSB-PA873687LA01HU
Size US$166
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  • Immunofluorescence staining of U251 cells with CSB-PA873687LA01HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CLDND1 Polyclonal antibody
Uniprot No.
Target Names
CLDND1
Alternative Names
CLDND1; C3orf4; HSPC174; PSEC0054; UNQ2511/PRO6000; Claudin domain-containing protein 1; Membrane protein GENX-3745
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Claudin domain-containing protein 1 protein (26-140AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The CLDND1 Antibody (Product code: CSB-PA873687LA01HU) is Non-conjugated. For CLDND1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA873687LB01HU CLDND1 Antibody, HRP conjugated ELISA
FITC CSB-PA873687LC01HU CLDND1 Antibody, FITC conjugated
Biotin CSB-PA873687LD01HU CLDND1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IF
Recommended Dilution
Application Recommended Dilution
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Gene References into Functions
  1. suggest that the transient decrease of CLDND1 after cerebellar hemorrhage is responsible for low-molecular-weight selective vascular hyperpermeability PMID: 28244141
  2. Z38 was overexpressed in clinical patients with RCC and was associated with RCC stage. Knockdown of Z38 in A498 and ACHIN cells inhibited cell proliferation and metastasis PMID: 28849012
  3. findings strongly suggest that CLDND1 is a direct RORalpha target PMID: 28130419
  4. CLDND1 as a novel survival factor in basal-like breast cancer cell lines PMID: 26083392
  5. A cDNA library consisting of 220 upregulated genes in tumour tissue was established and named as LSCC. Differential expression was confirmed in five of these genes, including IGFBP5, SQLE, RAP2B, CLDN1, and TBL1XR1. PMID: 17316888

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Subcellular Location
Membrane; Multi-pass membrane protein.
Protein Families
PMP-22/EMP/MP20 family
Tissue Specificity
Widely distributed in the adult CNS with highest expression in the corpus callosum, caudate nucleus, cerebral cortex, medulla, putamen, spinal cord, substantia nigra and subthalamic nucleus. Weak expression was detected in the adult heart.
Database Links

HGNC: 1322

KEGG: hsa:56650

STRING: 9606.ENSP00000388457

UniGene: Hs.531371

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