CLEC4G Antibody

Datasheet

Code	CSB-PA744269LA01HU
Size	US$166
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Image	IHC image of CSB-PA744269LA01HU diluted at 1:100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CLEC4G Polyclonal antibody

Uniprot No.

Q6UXB4

Target Names

CLEC4G

Alternative Names

C type lectin domain family 4; member G antibody; C type lectin superfamily 4; member G antibody; C-type lectin domain family 4 member G antibody; CLC4G_HUMAN antibody; Clec4g antibody; DTTR431 antibody; Liver and lymph node sinusoidal endothelial cell C type lectin antibody; LP2698 antibody; LSECtin antibody; UNQ431 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human C-type lectin domain family 4 member G protein (66-293AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CLEC4G Antibody (Product code: CSB-PA744269LA01HU) is Non-conjugated. For CLEC4G Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA744269LB01HU	CLEC4G Antibody, HRP conjugated	ELISA
FITC	CSB-PA744269LC01HU	CLEC4G Antibody, FITC conjugated
Biotin	CSB-PA744269LD01HU	CLEC4G Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Binds mannose, N-acetylglucosamine (GlcNAc) and fucose, but not galactose, in a Ca(2+)-dependent manner, in vitro.; (Microbial infection) Acts as a receptor for Japanese encephalitis virus.; (Microbial infection) Acts as a receptor for Ebolavirus.; (Microbial infection) Acts as a receptor for SARS-CoV.; (Microbial infection) Acts as a receptor for Lassa virus and Lymphocytic choriomeningitis virus glycoprotein.

Gene References into Functions

Japanese encephalitis virus infected cells through three virus receptors: DC-SIGN, DC-SIGNR and LSECtin. PMID: 24623090
The results indicate that LSECtin plays an important role in colorectal carcinoma liver metastasis and may be a promising new target for intervention in metastasis formation. PMID: 22637699
The mobility of LSECtin-carbohydrate recognition domain increased after addition of Ca(2+) and N-acetylglucosamine. PMID: 22711492
Axl,Tyro3,DC-SIGN and LSECtin are identified as new virus receptors for Lassa virus cell entry. PMID: 22156524
The human LSECtin have been shown to bind Ebola virus glycoprotein with equivalent affinities, and the GlcNAcbeta1-2Man disaccharide has been demonstrated to be an effective inhibitor of this interaction. PMID: 21257728
The interaction between CD44 & LSECtin is dependent on protein-glycan recognition. CD44 is the 1st identified endogenous ligand of LSECtin, & similarly, LSECtin is a novel ligand of CD44. PMID: 20127679
Observational study of gene-disease association. (HuGE Navigator) PMID: 20237496
results indicate that LSECtin is a novel member of a family of proteins comprising CD23, DC-SIGN, and DC-SIGNR and might function in vivo as a lectin receptor PMID: 14711836
LSECtin is a pathogen-associated molecular pattern receptor in human myeloid cells; results suggest that LSECtin participates in antigen uptake and internalization PMID: 17339424
Our results reveal important differences between Ebola virus and HIV-1 capture by DC-SIGN/R and LSECtin and hint towards different biological functions of these lectins. PMID: 18083206
LSECtin is expressed by liver myeloid cells, and its expression is dependent on the PU.1 transcription factor. PMID: 19111020
Liver sinusoidal endothelial cell lectin, LSECtin, negatively regulates hepatic T-cell immune response. PMID: 19632227
Observational study of gene-disease association. (HuGE Navigator) PMID: 18697825

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Subcellular Location

Cell membrane; Single-pass type II membrane protein.

Tissue Specificity

Expressed exclusively in fetal and adult liver and in lymph nodes. Specifically expressed by endothelial cells lining lymph node and liver sinuses (at protein level).

Database Links

HGNC: 24591

OMIM: 616256

KEGG: hsa:339390

STRING: 9606.ENSP00000327599

UniGene: Hs.220649

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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