CMTM8 Antibody

1. This is the first extensive study of CMTM8 expression in both normal and tumorous human tissues. Our findings strongly supported the potential role of CMTM8 as a novel tumor suppressor and may shape further functional studies on this gene PMID: 26574634
2. our data suggested that CMTM8 is an important tumor suppressor gene in human bladder cancer and qualified as a useful prognostic indicator for patients with bladder cancer. PMID: 26615421
3. overexpression of CMTM8 in bladder cancer results in reduced malignant cell growth, migration and invasion, which could make it a potential therapeutic target in the treatment of bladder cancer. PMID: 26503336
4. Down-regulation of CMTM8 also promoted an epithelial mesenchymal transition-like change in MCF-10A cells, indicating a broader role for CMTM8 in regulating cellular transformation. PMID: 22337876
5. These results identify CKLFSF8 as a novel regulator of EGF-induced signaling and indicate that the association of EGFR with four transmembrane proteins is critical for EGFR desensitization. PMID: 16263120
6. Cell proliferation and expression of EGFR of tumor cells can be inhibited by transfection of CKLFSF8. PMID: 16806010
7. These data implicate CMTM8 as a negative regulator of epidermal growth factor (EGF)-induced signaling. PMID: 17149703
8. The cloning and sequencing of an alternative splice form of CMTM8, obtained from a human blood cDNA library, that utilizes apoptotic pathways distinct from CMTM8, is reported. PMID: 17681841

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HGNC: 19179

OMIM: 607891

KEGG: hsa:152189

STRING: 9606.ENSP00000307741

UniGene: Hs.154986