CNOT1 Antibody

1. These results together with the authors' previous study, have identified that CNOT1 provides a platform for the recruitment of TTP and CNOT7, and is involved in TTPmediated ICAM1 and IL8 mRNA decay. PMID: 29956766
2. YTHDF2 recruits the CCR4-NOT complex through a direct interaction between the YTHDF2 N-terminal region and the SH domain of the CNOT1 subunit, and that this recruitment is essential for the deadenylation of m6A-containing RNAs by CAF1 and CCR4. PMID: 27558897
3. the CNOT1-LMNA-Hedgehog signaling pathway axis exerts an oncogenic role in osteosarcoma progression, which could be a potential target for gene therapy. PMID: 28188704
4. we demonstrate that joint deletion of two short conserved motifs that bind UNR and DDX6 relieves repression of 4E-T-bound mRNA, in part reliant on the 4E-T-DDX6-CNOT1 axis. PMID: 27342281
5. miRNAs, AGOs, GW182, the CCR4-NOT complex, and DDX6/Me31B repress and degrade polyadenylated mRNA targets that are translated via scanning-independent mechanisms in both human and Drosophila melanogaster cells PMID: 27009120
6. Single nucleotide polymorphism in CNOT1 gene is associated with osteosarcoma susceptibility. PMID: 25663449
7. CNOT1 facilitates recruitment of DDX6 to miRNA-targeted mRNAs, placing DDX6 as a downstream effector in the miRNA silencing pathway. PMID: 25035296
8. SNP rs7188697 A/G significantly associated with response to dendritic cells therapeutic HIV vaccine PMID: 24433985
9. Crystal structures of the DDX6, CNOT1 and CNOT9 complexes. PMID: 24768538
10. Crystal structure of the DDX6, CNOT9 and CNOT1 complex. PMID: 24768540
11. The CNOT2-CNOT3 heterodimer is stabilized and tightly anchored to the surface of CNOT1 through an unexpected intertwined arrangement of peptide regions lacking defined secondary structure. PMID: 24121232
12. Authors identify an evolutionarily conserved C-terminal motif in human TTP that directly binds a central domain of CNOT1, a core subunit of the CCR4-NOT complex. PMID: 23644599
13. The NOT1 MIF4G domain binds CAF1 through a pre-formed interface and leaves the CAF1 catalytic site fully accessible to RNA substrates. PMID: 22977175
14. Cnot1, Cnot2, and Cnot3 represent a novel component of the core self-renewal and pluripotency circuitry conserved in mouse and human ESCs. PMID: 22367759
15. Depletion of CNOT1 induces cell death in a caspase-dependent manner. PMID: 21976065
16. purification and characterization of 1.0 MDa yeast CCR4-NOT complex identifies two novel components, CAF40 and CAF130: yeast CAF40 binds human NOT1 PMID: 11733989
17. CNOT1 interacts in a ligand-dependent manner with RXR and represses transcription mediated by several RXR heterodimers. PMID: 16778766
18. Data show that Ccr4-Not function in RNA splicing and nuclear export, and that CNOT1 binds CNOT4 in yeast two-hybrid assays. PMID: 19558367

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HGNC: 7877

OMIM: 604917

KEGG: hsa:23019

STRING: 9606.ENSP00000320949

UniGene: Hs.460923