CNOT10 Antibody

Datasheet
Code CSB-PA884495LA01HU
See More Details
Size US$299
Uniprot No. Q9H9A5
Image
  • IHC image of CSB-PA884495LA01HU diluted at 1:400 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunogen Recombinant Human CCR4-NOT transcription complex subunit 10 protein (595-744AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, IHC; Recommended dilution: IHC:1:200-1:500
Relevance Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex.
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias CCR4-NOT transcription complex subunit 10, CNOT10
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Research Area Epigenetics and Nuclear Signaling
Target Names CNOT10
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex.
Subcellular Location Cytoplasm, Nucleus
Protein Families CNOT10 family
Database Links

HGNC: 23817

KEGG: hsa:25904

STRING: 9606.ENSP00000330060

UniGene: Hs.444851

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