CNOT8 Antibody

1. These results indicate that Caf1 and Ccr4 cooperate in mRNA deadenylation and suggest that the enzyme activities of Caf1 and Ccr4 are regulated via allosteric interactions within the nuclease module. PMID: 25944446
2. The loss of CAF-1 p48 subunit causes a strong defect in packaging DNA into nucleosomes. PMID: 24036545
3. show that SMG7 binds directly to POP2, a catalytic subunit of the CCR4-NOT deadenylase complex, and elicits deadenylation-dependent decapping and 5'-to-3' decay of NMD targets PMID: 24115769
4. The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex. PMID: 23236473
5. The NOT1 MIF4G domain binds CAF1 through a pre-formed interface and leaves the CAF1 catalytic site fully accessible to RNA substrates. PMID: 22977175
6. N-terminus played a role in modulating hCaf1 activity, stability and aggregation PMID: 22683897
7. Together, these results indicate that Tob mediates the recruitment of Caf1 to the target of CPEB3 and elicits deadenylation and decay of the mRNA. PMID: 21336257
8. Tob interactions with Caf1 and a C-terminal domain of PABPC1 PMID: 20595394
9. CCR4-NOT is the deadenylase that removes poly(A) from messages destabilized by miRNAs in human cells. PMID: 20065043
10. Cellular POP2 protein binds to central adaptor protein ASC and pathogen recognition receptor PAN1, blocking formation of cryopyrin and PAN1-containing inflammasomes, activation of caspase-1, and subsequent processing of bioactive interleukin-1 beta. PMID: 17178784
11. Data show that Ccr4-Not function in RNA splicing and nuclear export, and that CNOT8 binds CNOT6 in yeast two-hybrid assays. PMID: 19558367
12. Data show that efficient cell proliferation requires both CNOT7 and CNOT8, although combined knockdown of both subunits further reduces cell proliferation indicating partial redundancy between these proteins. PMID: 19605561

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HGNC: 9207

OMIM: 603731

KEGG: hsa:9337

STRING: 9606.ENSP00000285896

UniGene: Hs.26703