COA6 Antibody

Datasheet

Code	CSB-PA683360LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA683360LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) COA6 Polyclonal antibody

Uniprot No.

Q5JTJ3

Target Names

COA6

Alternative Names

COA6 antibody; C1orf31Cytochrome c oxidase assembly factor 6 homolog antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Cytochrome c oxidase assembly factor 6 homolog protein (1-125AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The COA6 Antibody (Product code: CSB-PA683360LA01HU) is Non-conjugated. For COA6 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA683360LB01HU	COA6 Antibody, HRP conjugated	ELISA
FITC	CSB-PA683360LC01HU	COA6 Antibody, FITC conjugated
Biotin	CSB-PA683360LD01HU	COA6 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomplexes comprised of complexes III and IV.

Gene References into Functions

Results find that COA6 associates with COX2 and is crucial for its maturation and complex IV biogenesis. Also, COA6 interacts with the copper chaperone SCO1 which indicates that COA6 is intrinsically involved in the copper delivery process for COX2. PMID: 26160915
Cooperation between COA6 and SCO2 in COX2 maturation during cytochrome c oxidase assembly links two mitochondrial cardiomyopathies. PMID: 25959673
Co-purified with C7orf44 (the human ortholog of fungal COX assembly protein) PMID: 22356826
COX assembly candidate, ortholog of fungal YMR244C-A PMID: 22356826
Strong candidate gene for mitochondrial disease, based on recessive mutations detected in infantile patients PMID: 22277967
Observational study of gene-disease association. (HuGE Navigator) PMID: 20877624

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Involvement in disease

Cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 4 (CEMCOX4)

Subcellular Location

Mitochondrion intermembrane space.

Protein Families

Cytochrome c oxidase subunit 6B family

Database Links

HGNC: 18025

OMIM: 614772

KEGG: hsa:388753

STRING: 9606.ENSP00000355572

UniGene: Hs.23198

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Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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