COL14A1 Antibody

Code CSB-PA142021
Size US$100
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  • Immunohistochemical analysis of paraffin-embedded human-skin, antibody was diluted at 1:200
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Product Details

Uniprot No.
Target Names
COL14A1
Alternative Names
COL14A1 antibody; UNDCollagen alpha-1(XIV) chain antibody; Undulin antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthetic peptide from Human protein at AA range: 1571-1620
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Purification Method
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Form
Liquid
Tested Applications
IHC,ELISA
Recommended Dilution
Application Recommended Dilution
IHC 1:50-300
ELISA 1:10000-20000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors.
Gene References into Functions
  1. the intima+media of IPAH vessels, collagens (COL4A5, COL14A1, and COL18A1), matrix metalloproteinase (MMP) 19, and a disintegrin and metalloprotease (ADAM) 33 were higher expressed, whereas MMP10, ADAM17, TIMP1, and TIMP3 were less abundant. PMID: 25840998
  2. COL14A1 would be a casual gene for punctate palmoplantar keratoderma. PMID: 22972947
  3. In addition to binding collagen I, COMP binds to collagens XII and XIV via their C-terminal collagenous domains. PMID: 22573329
  4. Results suggest that collagens XII and XIV might serve different functions during human embryonic development although their structures are highly similar. PMID: 15609093
  5. the fibronectin type III domain of collagen XIV is an inducer of quiescence and differentiation in fibroblasts and preadipocytes PMID: 16129687
  6. The aim of this study was therefore to test the association between polymorphisms within COL12A1 and COL14A1 and Achilles tendon injuries PMID: 17960519

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Subcellular Location
Secreted, extracellular space, extracellular matrix.
Protein Families
Fibril-associated collagens with interrupted helices (FACIT) family
Database Links

HGNC: 2191

OMIM: 120324

KEGG: hsa:7373

STRING: 9606.ENSP00000297848

UniGene: Hs.409662

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