COPS6 Antibody

1. High CSN6 expression is associated with metastasis of glioblastoma. PMID: 27546621
2. The overexpression of CSN6 reduced the effect of quercetin treatment on HT29 cells, suggesting that quercetininduced apoptosis may involve the AktCSN6Myc signaling axis in HT29 cells. PMID: 27748879
3. CSN6 positively regulates c-Jun in a MEKK1-dependent manner PMID: 26237449
4. our results indicate that CSN6 is a positive regulator of E6AP and is important for cervical cancer development. PMID: 26318036
5. CSN6 interacts with p27(Kip1) and facilitates ubiquitin-mediated degradation of p27(Kip1). PMID: 25945542
6. Findings indicate that the deregulation of beta-catenin by extracellular signal-regulated kinase 2 (ERK2)-activated CSN6 protein is important for colorectal cancer (CRC) development. PMID: 26267535
7. Analyses of the pseudo metal-binding motif in CSN6 suggest that the loss of two key histidine residues may contribute to the lack of catalytic activity in CSN6. PMID: 25242525
8. Data suggest that CSN6 is an important negative regulator of p57 (Kip2) , and that overexpression of CSN6 in many types of cancer could lead to decreased expression of p57 (Kip2) and result in promoted cancer cell growth. PMID: 23187808
9. COPS6 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. PMID: 21555518
10. loss of CSN6 enhances p53-mediated tumor suppression in vivo and CSN6 plays an important role in regulating DNA damage-associated apoptosis and tumorigenesis through control of the MDM2-p53 signaling pathway PMID: 21317535
11. critical role of caspase 8 in the processing of CSN6. PMID: 17337451
12. For the first time our data demonstrate that CSN-mediated deneddylation can be regulated by active Casp3 and that the CSN executes a specific function during the apoptotic process. PMID: 18060501

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HGNC: 21749

OMIM: 614729

KEGG: hsa:10980

STRING: 9606.ENSP00000304102

UniGene: Hs.15591