CPTP Antibody, FITC conjugated

Datasheet
Code CSB-PA719416LC01HU
Size US$299
Uniprot No. Q5TA50
Protocols ELISA Protocol
Immunogen Recombinant Human Ceramide-1-phosphate transfer protein (1-214AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Mediates the intracellular transfer of ceramide-1-phosphate between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and the release of arachidonic acid. Has no activity with galactosylceramide, lactosylceramide, sphingomyelin, phosphatidylcholine, phosphatidic acid and ceramide.
Form Liquid
Conjugate FITC
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Ceramide-1-phosphate transfer protein (CPTP) (Glycolipid transfer protein domain-containing protein 1) (GLTP domain-containing protein 1), CPTP, GLTPD1
Immunogen Species Homo sapiens (Human)
Research Area Signal Transduction
Target Names CPTP
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Mediates the intracellular transfer of ceramide-1-phosphate between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16
Subcellular Location Cytoplasm, cytosol, Golgi apparatus, trans-Golgi network membrane, Peripheral membrane protein, Cell membrane, Peripheral membrane protein, Cytoplasmic side, Endosome membrane, Peripheral membrane protein, Nucleus outer membrane, Peripheral membrane protein
Protein Families GLTP family
Tissue Specificity Ubiquitous. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes.
Database Links

HGNC: 28116

OMIM: 615467

KEGG: hsa:80772

STRING: 9606.ENSP00000343890

UniGene: Hs.515689

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