CRISP2 Antibody

1. low expression of CRISP2 protein rather than its mRNA was observed in the ejaculated spermatozoa from asthenoteratozoospermic patients as compared with normozoospermic males PMID: 27517483
2. Results identified CRISP2 as a potential binding protein of PSP94 from human sperm. PMID: 27161017
3. Crisp2 genetic defects in sperm from humans and mice result in male infertility. PMID: 26786179
4. Preliminary insight into the mechanism leading to the reduced CRISP2 expression in asthenozoospermia, offering a potential therapeutic target for treating male infertility or for male contraception. PMID: 25505194
5. Study shows the re-association of sperm acrosomal CRISP2 at the EqS during the acrosome reaction. Data showed that F-actin is not involved in the relocalization of CRISP2. Found that basic,but not acidic, conditions can solubilize CRISP2 from sperm cells. PMID: 23661501
6. CRISP2 rescues the phenotype of yeast mutants lacking Pry function and purified CRISP2 binds cholesterol in vitro, indicating that lipid binding is a conserved function of the CAP superfamily proteins. PMID: 23027975
7. The down-regulation of CRISP2 mRNA and protein expressions in the sperm of asthenospermia patients may be closely related with decreased sperm motility. PMID: 21485539
8. Additional transcription changes likely associated with Th2-like eosinophilic inflammation were prominent and included decreased CRISP2&3. PMID: 20625511
9. TPX1 is a component of the sperm acrosome that remains associated with sperm after capacitation and acrosome reaction , and is relevant for sperm-oocyte interaction. PMID: 15734896
10. The protein level and localization of TPX1 were altered in patients with spermatogenic arrest and in infertile men with oligoasthenoteratospermia syndrome. PMID: 16759931
11. Polymorphisms within the CRISP2 gene have no significant association with male infertility. PMID: 18550510

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HGNC: 12024

OMIM: 187430

KEGG: hsa:7180

STRING: 9606.ENSP00000339155

UniGene: Hs.2042