CRY1 Antibody

Datasheet
Code CSB-PA006005GA01HU
Size US$685
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Product Details

Uniprot No. Q16526
Target Names CRY1
Alternative Names Cry1 antibody; CRY1_HUMAN antibody; Cryptochrome 1 (photolyase like) antibody; Cryptochrome 1 antibody; Cryptochrome-1 antibody; PHLL1 antibody; Photolyase 1 antibody; Photolyase-like antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Human CRY1
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,WB,IF
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components
Gene References into Functions
  1. CRY-1 was expressed in 94% of the CLL patients at diagnosis. The median CRY-1 relative gene expression level (0.006) stratified patients into high and low expression groups. Forty of 100 (40%) CLL patients showed high CRY-1, 54/100 (54%) showed low CRY-1, and 6/100 (6%) had undetectable CRY-1 gene expression. PMID: 28884705
  2. Independent silencing of CRY1 and CRY2 genes in HAC15 cells resulted in a mild upregulation of HSD3B2 without affecting HSD3B1 expression. In conclusion, our results support the hypothesis that CRY1 and CRY2, being AngII-regulated genes, and showing a differential expression in APAs when compared with the adjacent adrenal cortex, might be involved in adrenal cell function, and in the regulation of aldosterone production PMID: 29874863
  3. The studies in this review reported contrasting results about the association of different single nucleotide polymorphisms (SNPs) in clock genes and Major Depressive Disorder. The most consistent result reported the association between SNP rs2287161 of CRY1 and MDD development. PMID: 29128257
  4. CRY1/2 serve as corepressors for many NRs. PMID: 28751364
  5. Study confirms the prognostic role of CRY1 in chronic lymphocytic leukemia, as its aberrant methylation and expression is associated with high risk of treatment initiation and survival. PMID: 28572861
  6. CRY1 SNP rs714359 showed nominally significant association with the problematicity of seasonal variations (problematic vs. no variation) of mood disorder. The set-based analysis did not support these associations. However, the CRY1 haplotype TAG including rs714359 showed nominally significant association with the problematicity of seasonal variations in mood disorder. PMID: 27267441
  7. CRY1 variants were not associated with major depressive disorder. PMID: 27721187
  8. Our findings suggest that CLOCK and CRY1 polymorphisms might be involved in individual susceptibility to abdominal obesity in Chinese Han population. PMID: 26923944
  9. Knockout-rescue embryonic stem cell-derived mouse reveals that CRY1 determines circadian period through both its degradation-dependent and -independent pathways. PMID: 28017587
  10. The present study identified USP7 and TDP-43 as the regulators of CRY1 and CRY2, underscoring the significance of the stability control process of CRY proteins for period determination in the mammalian circadian clockwork. PMID: 27123980
  11. Altered CRY1 and CRY2 expression patterns and the interplay with the genetic landscape in colon cancer cells may underlie phenotypic divergence. PMID: 26768731
  12. possible circadian rhythm in full-term placental expression PMID: 26247999
  13. Given the distinct characteristics of the C-terminal tails of the CRY1 and CRY2 proteins, our study addresses a long-standing hypothesis that the ratio of these two CRY molecules affects the clock period. PMID: 26966073
  14. Overexpression of CRY1 protects against the development of atherosclerosis via the TLR/NFkappaB pathway PMID: 26218278
  15. Collectively, these data show that KPNB1 is required for timely nuclear import of PER/CRY in the negative feedback regulation of the circadian clock. PMID: 26319354
  16. these observations suggest a biologically plausible season-dependent association between SNPs at CRY1, CRY2 and MTNR1B and glucose homeostasis. PMID: 25707907
  17. CRY1 and CRY2 variants showed nominal association with the metabolic syndrome components, hypertension and triglyceride levels. PMID: 25391456
  18. In men undergoing acute total sleep deprivation, there was increased methylation in the promoter of CRY1 in adipose tissue compared with controls. Also decreased gene expression in skeletal muscle. PMID: 26168277
  19. SNPs in CRY1 were significantly associated with overall survival in Chinese hepatocellular carcinoma patients. PMID: 25344870
  20. Study reveals an interaction between a CRY1 variant and carbohydrate intake for glucose metabolism. PMID: 24548145
  21. findings show the polymorphisms of Cry1 rs2287161 and Tef rs738499 are associated to major depressive disorder in the Chinese population PMID: 24581835
  22. Casein kinase 1 primarily regulates the accumulating phase of the PER-CRY repressive complex by controlling the nuclear import rate. PMID: 24449901
  23. data suggest a new role for the C-terminal tail of CRY1 in which phosphorylation rhythmically regulates CRY1 stability and contributes to the proper circadian period length PMID: 24158435
  24. Cry1 likely plays important roles in colorectal cancer development and progression. PMID: 23626715
  25. Data suggest that clock genes Per1, Cry1, Clock, and Bmal1 and their protein products may be directly involved in the daytime-dependent regulation and adaptation of hormone synthesis. PMID: 23584858
  26. Studies indicate that in the cytoplasm, PER3 protein heterodimerizes with PER1, PER2, CRY1, and CRY2 proteins and enters into the nucleus, resulting in repression of CLOCK-BMAL1-mediated transcription. PMID: 23546644
  27. Reduced cry1 expression is associated with glioma. PMID: 23317246
  28. Loss of Cry1 expression is associated with skin tumors. PMID: 23242607
  29. type II protein arginine methyltransferase 5 has a role in the regulation of Circadian Per1 and CRY1 genes PMID: 23133559
  30. Genetic variants of CRY1 associate with depressive disorder. PMID: 22538398
  31. USP2a potentially mediates circadian disruption by suppressing the CRY1 degradation during inflammation. PMID: 22669941
  32. the CRY1-PHR domain(313-426), not the divergent C-terminal domain, is critical for clock function. PMID: 22692217
  33. Human cryptochrome-1 confers light independent biological activity in transgenic Drosophila correlated with flavin radical stability. PMID: 22427812
  34. The methylation pattern of the CRY1 promoter proved to have high prognostic impact in CLL where aberrant promoter methylation predicted a favourable outcome. PMID: 22470559
  35. Clock genes expression is sex dependent in human adipose tissue from morbidly obese subjects and correlates to a decreased in metabolic syndrome-related traits. PMID: 22081238
  36. Five SNPs were validated as being significantly associated with prostate cancer mortality, one each in the LEPR, CRY1, RNASEL, IL4, and ARVCF genes. PMID: 21846818
  37. There was no circadian rhythm of bmal1(brain and muscle ARNT-like 1) and cry1(cryptochrome 1) in PBMC of preterm neonates PMID: 20222832
  38. Linkage disequilibrium analyses using single SNPs and haplotypes showed no association to bipolar disease. PMID: 15722957
  39. the CLOCK(NPAS2)/BMAL1 complex is post-translationally regulated by cry1 and cry2 PMID: 16628007
  40. Cry1 may be a candidate gene of schizophrenia. The proposition may have new clues on the development of genetic study on complex diseases PMID: 17376600
  41. The regulators of clock-controlled transcription PER2, CRY1 and CRY2 differ in their capacity to interact with each single component of the BMAL1-CLOCK heterodimer and, in the case of BMAL1, also in their interaction sites. PMID: 18430226
  42. Cryptochrome-1 was a valuable predictor of disease progression in early-stage chronic lymphocytic leukemia PMID: 19181792
  43. differential expression and prognostic significance of the circadian genes CRY1 and PER2 in chronic lymphocytic leukemia PMID: 19500131

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Involvement in disease Delayed sleep phase syndrome (DSPS)
Subcellular Location Cytoplasm, Nucleus
Protein Families DNA photolyase class-1 family
Database Links

HGNC: 2384

OMIM: 601933

KEGG: hsa:1407

STRING: 9606.ENSP00000008527

UniGene: Hs.151573

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