CRYZ Antibody

Code CSB-PA600843LA01HU
Size US$166
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Image
  • IHC image of CSB-PA600843LA01HU diluted at 1:400 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • IHC image of CSB-PA600843LA01HU diluted at 1:400 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CRYZ Polyclonal antibody
Uniprot No.
Target Names
CRYZ
Alternative Names
Crystallin zeta (quinone reductase) antibody; Crystallin zeta antibody; Cryz antibody; DKFZp779E0834 antibody; FLJ41475 antibody; NADPH:quinone reductase antibody; QOR_HUMAN antibody; Quinone oxidoreductase antibody; Zeta crystallin antibody; Zeta-crystallin antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Quinone oxidoreductase protein (47-109AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The CRYZ Antibody (Product code: CSB-PA600843LA01HU) is Non-conjugated. For CRYZ Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA600843LB01HU CRYZ Antibody, HRP conjugated ELISA
FITC CSB-PA600843LC01HU CRYZ Antibody, FITC conjugated
Biotin CSB-PA600843LD01HU CRYZ Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:200-1:500
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding.
Gene References into Functions
  1. Our results suggest that genetic variants in TYW3/CRYZ and NDST4 loci may be involved in the regulation of circulating resistin levels PMID: 22843503
  2. role of Zta1p in the yeast adaptation to some stress types and the general functional significance of zeta-crystallins PMID: 21276778
  3. novel enzymatic activity for human zeta-crystallin, the double- bond a,b-hydrogenation of 2-alkenals and 3-alkenones, was identified. PMID: 20835842
  4. zeta-Crystallin is a bcl-2 mRNA binding protein involved in bcl-2 overexpression in T-cell acute lymphocytic leukemia. PMID: 20103721
  5. up-regulation of quinone reductase can protect breast cells against oxidative DNA damage PMID: 12714703

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Subcellular Location
Cytoplasm.
Protein Families
Zinc-containing alcohol dehydrogenase family, Quinone oxidoreductase subfamily
Tissue Specificity
Only very low amounts in the lens.
Database Links

HGNC: 2419

OMIM: 123691

KEGG: hsa:1429

STRING: 9606.ENSP00000339399

UniGene: Hs.83114

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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