CRYZ Antibody

Datasheet

Code	CSB-PA600843LA01HU
Size	US$166
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Image	IHC image of CSB-PA600843LA01HU diluted at 1:400 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. IHC image of CSB-PA600843LA01HU diluted at 1:400 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CRYZ Polyclonal antibody

Uniprot No.

Q08257

Target Names

CRYZ

Alternative Names

Crystallin zeta (quinone reductase) antibody; Crystallin zeta antibody; Cryz antibody; DKFZp779E0834 antibody; FLJ41475 antibody; NADPH:quinone reductase antibody; QOR_HUMAN antibody; Quinone oxidoreductase antibody; Zeta crystallin antibody; Zeta-crystallin antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Quinone oxidoreductase protein (47-109AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CRYZ Antibody (Product code: CSB-PA600843LA01HU) is Non-conjugated. For CRYZ Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA600843LB01HU	CRYZ Antibody, HRP conjugated	ELISA
FITC	CSB-PA600843LC01HU	CRYZ Antibody, FITC conjugated
Biotin	CSB-PA600843LD01HU	CRYZ Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:200-1:500

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding.

Gene References into Functions

Our results suggest that genetic variants in TYW3/CRYZ and NDST4 loci may be involved in the regulation of circulating resistin levels PMID: 22843503
role of Zta1p in the yeast adaptation to some stress types and the general functional significance of zeta-crystallins PMID: 21276778
novel enzymatic activity for human zeta-crystallin, the double- bond a,b-hydrogenation of 2-alkenals and 3-alkenones, was identified. PMID: 20835842
zeta-Crystallin is a bcl-2 mRNA binding protein involved in bcl-2 overexpression in T-cell acute lymphocytic leukemia. PMID: 20103721
up-regulation of quinone reductase can protect breast cells against oxidative DNA damage PMID: 12714703

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Subcellular Location

Cytoplasm.

Protein Families

Zinc-containing alcohol dehydrogenase family, Quinone oxidoreductase subfamily

Tissue Specificity

Only very low amounts in the lens.

Database Links

HGNC: 2419

OMIM: 123691

KEGG: hsa:1429

STRING: 9606.ENSP00000339399

UniGene: Hs.83114

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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