CWC22 Antibody

Datasheet

Code	CSB-PA875721LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA875721LA01HU at dilution of 1:100 Immunofluorescent analysis of Hela cells using CSB-PA875721LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CWC22 Polyclonal antibody

Uniprot No.

Q9HCG8

Target Names

CWC22

Alternative Names

CWC22 antibody; CWC22 spliceosome associated protein homolog (S. cerevisiae) antibody; CWC22 spliceosome associated protein homolog antibody; CWC22_HUMAN antibody; EIF4GL antibody; fSAPb antibody; Functional spliceosome associated protein b antibody; KIAA1604 antibody; NCM antibody; Nucampholin homolog antibody; Pre-mRNA-splicing factor CWC22 homolog antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Pre-mRNA-splicing factor CWC22 homolog protein (360-623AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CWC22 Antibody (Product code: CSB-PA875721LA01HU) is Non-conjugated. For CWC22 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA875721LB01HU	CWC22 Antibody, HRP conjugated	ELISA
FITC	CSB-PA875721LC01HU	CWC22 Antibody, FITC conjugated
Biotin	CSB-PA875721LD01HU	CWC22 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Required for pre-mRNA splicing as component of the spliceosome. Promotes exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay.

Gene References into Functions

The binding mode of CWC22 to eIF4AIII reveals a facet of how MIF4G domains use their versatile structural frameworks to activate or inhibit DEAD-box proteins. PMID: 24218557
CWC22 connects pre-mRNA splicing and exon junction complex assembly. PMID: 22959432
The essential splicing factor CWC22 has acquired functions in exon junction complex assembly and nonsense-mediated decay during evolution from single-celled to complex eukaryotes. PMID: 23236153
CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly PMID: 22961380

Subcellular Location

Nucleus. Nucleus speckle.

Protein Families

CWC22 family

Database Links

HGNC: 29322

OMIM: 615186

KEGG: hsa:57703

STRING: 9606.ENSP00000387006

UniGene: Hs.311363

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Service

Phage Display Service

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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