CYBRD1 Antibody

Datasheet

Code	CSB-PA006326LA01HU
Size	US$166
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Image	Immunofluorescence staining of Hela cells with CSB-PA006326LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CYBRD1 Polyclonal antibody

Uniprot No.

Q53TN4

Target Names

CYBRD1

Alternative Names

CYBRD1; DCYTB; FRRS3; Plasma membrane ascorbate-dependent reductase CYBRD1; Cytochrome b reductase 1; Duodenal cytochrome b; Ferric-chelate reductase 3

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Cytochrome b reductase 1 protein (220-286AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CYBRD1 Antibody (Product code: CSB-PA006326LA01HU) is Non-conjugated. For CYBRD1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA006326LB01HU	CYBRD1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA006326LC01HU	CYBRD1 Antibody, FITC conjugated
Biotin	CSB-PA006326LD01HU	CYBRD1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IF

Recommended Dilution

Application	Recommended Dilution
IF	1:200-1:500

Protocols

ELISA Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Plasma membrane reductase that uses cytoplasmic ascorbate as an electron donor to reduce extracellular Fe(3+) into Fe(2+). Probably functions in dietary iron absorption at the brush border of duodenal enterocytes by producing Fe(2+), the divalent form of iron that can be transported into enterocytes. It is also able to reduce extracellular monodehydro-L-ascorbate and may be involved in extracellular ascorbate regeneration by erythrocytes in blood. May also act as a ferrireductase in airway epithelial cells. May also function as a cupric transmembrane reductase.

Gene References into Functions

Single nucleotide polymorphism in CYBRD1 gene is associated with hemochromatosis. PMID: 28937159
CYBRD1 has an involvement in iron homeostasis in chronic hepatitis C. PMID: 27439017
DCYTB is an important predictor of outcome and is associated with response to therapy in breast cancer patients. PMID: 28270217
Polymorphisms in CYBRD1 modulates iron phenotype in HFE p.C282Y homozygous hemochromatosis. PMID: 22773607
Letter: report mutations in CYBRD1 promoter in and possible role in iron hemostasis in patients with porphyria cutanea tarda. PMID: 23012398
In Africans with iron overload not related to the HFE gene, the possible involvement of the SLC40A1 and CYBRD1 genes was demonstrated for the first time. PMID: 15338274
Duodenal cytochrome b present in human erythrocytes may contribute to their ability to reduce extracellular monodehydroascorbate. PMID: 17068337
The current study concerns the recombinant expression, purification, and initial spectroscopic characterization of a recombinant form of the human ferric reductase. PMID: 18092813
Functional characterization of Cybrd1 heme groups and iron/ascorbate metabolism. PMID: 18194661
The results of this study confirm that Dcytb can act as a ferric reductase that stimulates iron uptake in Caco-2 cells. PMID: 18492824

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Subcellular Location

Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein.

Tissue Specificity

Present in erythrocyte membranes (at protein level). Also expressed in respiratory epithelium.

Database Links

HGNC: 20797

OMIM: 605745

KEGG: hsa:79901

STRING: 9606.ENSP00000319141

UniGene: Hs.221941

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