CYBRD1 Antibody

Datasheet

Code	CSB-PA006326LA01HU
Size	US$166
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Image	Immunofluorescence staining of Hela cells with CSB-PA006326LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CYBRD1 Polyclonal antibody

Uniprot No.

Q53TN4

Target Names

CYBRD1

Alternative Names

CYBRD1; DCYTB; FRRS3; Plasma membrane ascorbate-dependent reductase CYBRD1; Cytochrome b reductase 1; Duodenal cytochrome b; Ferric-chelate reductase 3

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Cytochrome b reductase 1 protein (220-286AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CYBRD1 Antibody (Product code: CSB-PA006326LA01HU) is Non-conjugated. For CYBRD1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA006326LB01HU	CYBRD1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA006326LC01HU	CYBRD1 Antibody, FITC conjugated
Biotin	CSB-PA006326LD01HU	CYBRD1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IF

Recommended Dilution

Application	Recommended Dilution
IF	1:200-1:500

Protocols

ELISA Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Plasma membrane reductase that uses cytoplasmic ascorbate as an electron donor to reduce extracellular Fe(3+) into Fe(2+). Probably functions in dietary iron absorption at the brush border of duodenal enterocytes by producing Fe(2+), the divalent form of iron that can be transported into enterocytes. It is also able to reduce extracellular monodehydro-L-ascorbate and may be involved in extracellular ascorbate regeneration by erythrocytes in blood. May also act as a ferrireductase in airway epithelial cells. May also function as a cupric transmembrane reductase.

Gene References into Functions

Single nucleotide polymorphism in CYBRD1 gene is associated with hemochromatosis. PMID: 28937159
CYBRD1 has an involvement in iron homeostasis in chronic hepatitis C. PMID: 27439017
DCYTB is an important predictor of outcome and is associated with response to therapy in breast cancer patients. PMID: 28270217
Polymorphisms in CYBRD1 modulates iron phenotype in HFE p.C282Y homozygous hemochromatosis. PMID: 22773607
Letter: report mutations in CYBRD1 promoter in and possible role in iron hemostasis in patients with porphyria cutanea tarda. PMID: 23012398
In Africans with iron overload not related to the HFE gene, the possible involvement of the SLC40A1 and CYBRD1 genes was demonstrated for the first time. PMID: 15338274
Duodenal cytochrome b present in human erythrocytes may contribute to their ability to reduce extracellular monodehydroascorbate. PMID: 17068337
The current study concerns the recombinant expression, purification, and initial spectroscopic characterization of a recombinant form of the human ferric reductase. PMID: 18092813
Functional characterization of Cybrd1 heme groups and iron/ascorbate metabolism. PMID: 18194661
The results of this study confirm that Dcytb can act as a ferric reductase that stimulates iron uptake in Caco-2 cells. PMID: 18492824

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Subcellular Location

Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein.

Tissue Specificity

Present in erythrocyte membranes (at protein level). Also expressed in respiratory epithelium.

Database Links

HGNC: 20797

OMIM: 605745

KEGG: hsa:79901

STRING: 9606.ENSP00000319141

UniGene: Hs.221941

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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