DARS Antibody

Datasheet

Code	CSB-PA006505LA01HU
Size	US$166
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) DARS Polyclonal antibody

Uniprot No.

P14868

Target Names

DARS

Alternative Names

Aspartate tRNA ligase 1 cytoplasmic antibody; Aspartate tRNA ligase antibody; Aspartate--tRNA ligase antibody; Aspartyl tRNA synthetase antibody; Aspartyl tRNA synthetase cytoplasmic antibody; Aspartyl-tRNA synthetase antibody; AspRS antibody; Cell proliferation inducing gene 40 protein antibody; Cell proliferation inducing protein 40 antibody; Cell proliferation-inducing gene 40 protein antibody; cytoplasmic antibody; Dars antibody; DKFZp781B11202 antibody; MGC111579 antibody; SYDC_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Aspartate--tRNA ligase, cytoplasmic protein (1-300AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The DARS Antibody (Product code: CSB-PA006505LA01HU) is Non-conjugated. For DARS Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA006505LB01HU	DARS Antibody, HRP conjugated	ELISA
FITC	CSB-PA006505LC01HU	DARS Antibody, FITC conjugated
Biotin	CSB-PA006505LD01HU	DARS Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.

Gene References into Functions

Genetic variants of the DARS gene may influence individual susceptibility to isolated VSD in Chinese Han population. Risk of VSD was significantly associated with rs2164331 [G/A; odds ratio (OR) = 0.78, 95% confidence interval (CI) = 0.69-0.91; P = 3.17 x 10(-3)], rs6738266 [G/A; OR = 1.17, 95% CI = 1.05-1.29, P = 1.83 x 10(-3)], and rs309143 [G/A; OR = 1.09, 95% CI = 1.01-1.17; P = 3.12 x 10(-2)]. PMID: 27871331
Report on the crystal structure of human cytosolic aspartyl-tRNA synthetase (DRS) at a resolution of 2.25 A. PMID: 23609930
Mutations in DARS cause hypomyelination with brain stem and spinal cord involvement and leg spasticity. PMID: 23643384
the N-terminus shows a less-ordered structure with flexible beta-turn, suggesting that when tRNA is stretched, the dissociation rate of Asp-tRNA from aspartyl-tRNA synthetase is reduced, giving time for elongation factor 1alpha to interact with Asp-tRNA. PMID: 12824064

Involvement in disease

Hypomyelination with brainstem and spinal cord involvement and leg spasticity (HBSL)

Subcellular Location

Cytoplasm, cytosol.

Protein Families

Class-II aminoacyl-tRNA synthetase family, Type 2 subfamily

Tissue Specificity

Expression in the developing and adult brain shows similar patterns. Highly expressed in the ventricular and subventricular zones, including hippocampal subfields, the midlateral temporal cortex and the frontal polar cortex. The cerebellum, cerebral corte

Database Links

HGNC: 2678

OMIM: 603084

KEGG: hsa:1615

STRING: 9606.ENSP00000264161

UniGene: Hs.503787

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