DCC Antibody

1. Based on the variable expressivity and incomplete penetrance present in heterozygous carriers of a DCC variant, classification and clinical interpretation of missense variants is challenging in the absence of evidence of pathogenicity originated from functional studies PMID: 29366874
2. Study results indicate that DCC controls corticospinal tract midline crossing in both humans and mice, and that this process is non cell-autonomous in mice. PMID: 28341853
3. rs2229080 and rs7504990 polymorphisms in DCC might be related with breast cancer susceptibility in Chinese women. PMID: 27127179
4. Somatic DCC mutations are associated with metastatic NUT midline carcinoma. PMID: 28967088
5. Authors demonstrate that tripartite motif protein 9 (TRIM9)-dependent ubiquitination of DCC blocks the interaction with and phosphorylation of FAK. PMID: 28701345
6. Environmental and endogenous proteases may contribute to cancer development by depleting DCC and neogenin. PMID: 27716118
7. Identified DCC mutations in four families. PMID: 28250454
8. DCC polymorphism maybe responsible for successful treatment of patients with hydrochlorothiazide . diagnosed with hypertension. PMID: 27381900
9. Deleted in colorectal cancer (DCC) confers susceptibility to depression-like behaviors in humans and mice and Is regulated by miR-218. By regulating DCC, miR-218 may be a switch of susceptibility versus resilience to stress-related disorders. PMID: 27773352
10. DCC/18q and ERBB2/17q gene copy number variations are associated with disease-free survival in microsatellite stable colon cancer PMID: 28006840
11. Allelic and genotypic frequencies of the DCC polymorphism rs2229080 were nominally associated with schizophrenia. PMID: 27055860
12. Results of APC and DCC LOH, KRAS and microsatellite instability indicate our colorectal cancer cases were typical of sporadic cancers following the 'chromosomal instability' pathway. PMID: 26970738
13. The study identified DCC as a differentially expressed gene and clustered meningiomas into DCC low expression (3 grade I and 3 grade II tumors), DCC medium expression (2 grade I and 1 grade II tumors), and DCC high expression (5 grade I tumors) groups. PMID: 27096627
14. Data suggest that, in response to netrin-1/netrin receptor (DCC) signaling, p120RasGAP is recruited to growth cones and supports axon outgrowth; p120RasGAP Src homology 2 domains exhibit scaffolding properties sufficient to support axon outgrowth. PMID: 26710849
15. By analyzing multiple myeloma-derived cell lines and patient-derived primary CD138-positive plasma cells ... authors show for the first time that transcriptional dysregulation of DCC is involved in the progression of plasma cell malignancy. PMID: 26390996
16. the transfected DCC gene can suppress cell proliferation and lead to downregulation of CEA expression in SW1116 cells. PMID: 26345965
17. Signaling mechanism of the netrin-1 receptor DCC in axon guidance PMID: 25881791
18. NTN1-DCC pathway contains targets of FDA-approved drugs and may offer promise for guiding applied clinical research on preventive and therapeutic interventions for AMD PMID: 25950802
19. DCC mutation correlated with fractionated mirroring in individuals with Congenital mirror movements PMID: 25813273
20. Data show that silencing ezrin-radixin-moesin (ERM) protein expression ablates deleted in colorectal carcinoma protein (DCC)-protein kinase A (PKA) interaction and specifically blocks netrin-induced PKA activity and phosphorylation. PMID: 25575591
21. Three novel truncating mutations of DCC are associated with congenital mirror movements. PMID: 24808016
22. EDNRB and/or DCC methylation in salivary rinses compares well to examination by an expert clinician in CRC of oral lesions. PMID: 23637120
23. genetic variations in DCC rs714 (A>G) modulate risk of esophageal and gastric cancers in a high-risk Kashmir population. PMID: 23765761
24. Ethnic Malays is genetically susceptible to H. pylori infection and is possibly mediated through a genetic variation in the DCC gene. PMID: 22829558
25. results suggested that cohypermethylation of p14 in combination with DCC and/or CADM1 may be an independent prognostic factor for recurrence in patients with stage I ESCC PMID: 23310950
26. Netrin-1 and DCC are increased in diseased lumbar intervertebral discs and may play a role in the process of neurovascular growth. PMID: 22588384
27. This study re-affirms the role of plausible tumor suppressor DCC variants, in gallbladder carcinogenesis and the risk haplotype may be explored as a useful marker for gallbladder cancer susceptibility. PMID: 23353777
28. The results of this study suggested that DCC as a promising novel candidate gene that may contribute to the genetic basis behind individual differences in susceptibility to schizophrenia. PMID: 22418395
29. SNP rs7504990 in the DCC showed genome-wide significant association with gallbladder cancer susceptibility. PMID: 22318345
30. An unexpected binding mode of the DCC peptide to the subdomain C groove of the FERM domain, which is distinct from previously reported beta-beta associations found in radixin-adhesion molecule complexes. PMID: 21642953
31. Lost expression of DCC gene is associated with ovarian cancer. PMID: 20054719
32. study reports a novel DCC gene mutation responsible for congenital isolated persistent mirror movements in an Italian family and provide evidence that this entity is genetically heterogeneous PMID: 21242494
33. our findings might indicate also an important role for DCC and netrin-1 in human foetal central nervous system development PMID: 20609112
34. study found that individuals affected with congenital mirror movements carried protein-truncating mutations in DCC; mutant DCC protein revealed a defect in netrin-1 binding; DCC has an important role in lateralization of the nervous system PMID: 20431009
35. DCC methylation was observed in the course of gastric carcinogenesis and disappeared in advanced gastric carcinoma. PMID: 20150623
36. DCC receptor is localized to syncytiotrophoblasts and invasive extravillous cytotrophoblasts during the first trimester and at term. PMID: 19826074
37. Altered expression of DCC protein is detectable in gastric carcinomas, an event that may have a role in the development of the disease. PMID: 11518545
38. The netrin-1 receptor DCC promotes filopodia formation and cell spreading by activating Cdc42 and Rac1. PMID: 11817894
39. Loss of dcc gene expression is associated with acute myelogenous leukemia PMID: 12060632
40. loss of DCC expression occurs in some colon adenomas, but is insufficient to drive the adenoma to carcinoma progression. PMID: 12432238
41. data suggest that the codon 201 polymorphism of the DCC gene was a target of LOH, and predicted prognosis in colorectal cancer patients PMID: 12787729
42. DCC binds to netrin, which regulates its interactions with heparin PMID: 12810718
43. Prognostic significance of the DCC gene protein expression in high-risk resected gastric carcinoma PMID: 12901278
44. Deletions in this gene are found in colorectal and gastric cancers PMID: 12901294
45. Multiple aberrations involving the DCC locus may play a role in the progression of nephroblastomas, and hence confer a poorer prognosis. PMID: 14631365
46. DCC/netrin-1 signaling may commit cells to the transition of endometrial gland architecture or function from a proliferating to a secretory phase. PMID: 15491747
47. Binding of netrin-1 to its receptors inhibits tumour suppressor p53-dependent apoptosis (review) PMID: 15573119
48. DCC binds netrin through the fourth fibronectin type III domain. PMID: 15574733
49. DCC expression appears not to be predictive in poor survival outcome in patients with stage II or III colorectal cancer. PMID: 15722793
50. DCC in both commissural neurons and immortalized cells, is partially associated with cholesterol- and sphingolipid-enriched membrane domains named lipid rafts. PMID: 15811950

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HGNC: 2701

OMIM: 120470

KEGG: hsa:1630

STRING: 9606.ENSP00000389140

UniGene: Hs.162025