DCHS1 Antibody

Datasheet
Code CSB-PA850320OA01HU
See More Details Free Antibody trial simple
Size US$299
Uniprot No. Q96JQ0
Image
  • IHC image of CSB-PA850320OA01HU diluted at 1:100 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • Immunofluorescence staining of SH-SY5Y cells with CSB-PA850320OA01HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Immunogen Peptide sequence from Human Protocadherin-16 protein (2964-2981AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200
Relevance Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation. In the heart, has a critical role for proper morphogenesis of the mitral valve, acting in the regulation of cell migration involved in valve formation (PubMed:26258302).
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Antigen Affinity Purified
Isotype IgG
Clonality Polyclonal
Alias Protocadherin-16 (Cadherin-19) (Cadherin-25) (Fibroblast cadherin-1) (Protein dachsous homolog 1), DCHS1, CDH19 CDH25 FIB1 KIAA1773 PCDH16
Immunogen Species Homo sapiens (Human)
Research Area Signal Transduction
Target Names DCHS1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation. In the heart, has a critical role for proper morphogenesis of the mitral valve, acting in the regulation of cell migration involved in valve formation
Involvement in disease Van Maldergem syndrome 1 (VMLDS1); Mitral valve prolapse 2 (MVP2)
Subcellular Location Cell membrane, Single-pass type I membrane protein
Tissue Specificity Expressed in fibroblasts but not in melanocytes or keratinocytes.
Database Links

HGNC: 13681

OMIM: 601390

KEGG: hsa:8642

STRING: 9606.ENSP00000299441

UniGene: Hs.199850

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