DEFA4 Antibody

Code CSB-PA007746
Size US$100
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Product Details

Uniprot No.
Target Names
DEFA4
Alternative Names
DEFA4 antibody; DEF4Neutrophil defensin 4 antibody; Defensin antibody; alpha 4 antibody; HNP-4 antibody; HP-4 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from the Internal region of Human Defensin α4.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
IHC, ELISA
Recommended Dilution
Application Recommended Dilution
IHC 1:100-1:300
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production.
Gene References into Functions
  1. DEFA4 displays antimicrobial activity against E. coli, S. faecalis, and C. albicans. PMID: 2500436
  2. DEFA1-3 and DEFA4 mRNA level in peripheral blood cells can be used to identify chronic myeloid leukaemia patients who are at risk of being imatinib-resistant, before initiation of the therapy. PMID: 21734341
  3. The combination of an increased expression of the antimicrobial peptide DEFA-4, the oncogene S100-A7, epidermal growth factor, and tenascin-c, and a decreased Doc-1 expression in oral leukoplakia might characterize its potency of malignant transformation. PMID: 20727496
  4. Crystal structure of HNP-4. PMID: 17088326
  5. DEFA4 was upregulated in IPF patients with acute exacerbation PMID: 19363140

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Subcellular Location
Secreted.
Protein Families
Alpha-defensin family
Database Links

HGNC: 2763

OMIM: 601157

KEGG: hsa:1669

STRING: 9606.ENSP00000297435

UniGene: Hs.591391

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