DENND1A Antibody

1. The association of DENND1A rs10818854 and rs10986105 variants with PCOS in Tunisian but not Bahraini women confirms the dependence of this association on the ethnic/racial origin of study subjects. PMID: 29325736
2. Genome-wide association studies have identified DENND1A as a candidate gene for polycystic ovary syndrome (PCOS). PCOS theca cells are shown to overexpress DENND1A splice variant 2 (V2), but not V1. Also, the genetic variation 330 bp upstream of exon 20A is not associated with VE variant expression. PMID: 27297658
3. DENND1A gene variant is likely to have influence on PCOS risk. PMID: 27488699
4. This meta-analysis suggested that rs2479106 and rs10818854 polymorphisms in the DENND1A gene were associated with increased risk of polycystic ovary syndrome PMID: 26757598
5. The guanine nucleotide exchange factor activity of connecdenn 1 and 2 are autoinhibited, and this is regulated by Akt activation downstream of insulin stimulation. PMID: 26055712
6. We demonstrated lack of association of DENND1A SNPs rs10818854, rs2479106, and rs10986105, previously associated with PCOS in Asians, with PCOS in Bahraini Arab women. PMID: 25626177
7. sequence analysis of the DENND1A gene of patients with PCOS did not identify alterations that alone could be responsible for the PCOS pathogenesis PMID: 24086769
8. DENND1A, plays a key role in the hyperandrogenemia associated with polycystic ovary syndrome. PMID: 24706793
9. THADA and DENND1A, carry risk alleles that are associated with endocrine and metabolic disturbances in PCOS patients of Han Chinese descent. PMID: 23208300
10. Our results suggest that SNPs rs2479106 in gene DENND1A and rs13405728 in gene LHCGR are associated with endometrioid adenocarcinoma. PMID: 22902918
11. The rs2479106 G allele was associated with decreased PCOS susceptibility PMID: 22504079
12. Variants in DENND1A are associated with polycystic ovary syndrome in women of European ancestry. PMID: 22547425
13. At least two of the PCOS susceptibility loci identified in the Chinese PCOS GWAS (DENND1A and THADA) are also associated with PCOS in European derived populations. PMID: 22180642

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HGNC: 29324

OMIM: 613633

KEGG: hsa:57706

STRING: 9606.ENSP00000362727

UniGene: Hs.744995