DIS3L2 Antibody

Datasheet

Code	CSB-PA818258LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human ovarian tissue using CSB-PA818258LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human bladder cancer using CSB-PA818258LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) DIS3L2 Polyclonal antibody

Uniprot No.

Q8IYB7

Target Names

DIS3L2

Alternative Names

DI3L2_HUMAN antibody; DIS3 L2 antibody; DIS3 mitotic control homolog (S. cerevisiae) like 2 antibody; DIS3 mitotic control homolog like 2 antibody; DIS3-like exonuclease 2 antibody; Dis3l2 antibody; FLJ36974 antibody; MGC42174 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human DIS3-like exonuclease 2 protein (201-400AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The DIS3L2 Antibody (Product code: CSB-PA818258LA01HU) is Non-conjugated. For DIS3L2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA818258LB01HU	DIS3L2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA818258LC01HU	DIS3L2 Antibody, FITC conjugated
Biotin	CSB-PA818258LD01HU	DIS3L2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.

Gene References into Functions

The evidence has been presented that Dis3l2 controls miRNA-9 production. PMID: 27881476
Our findings establish the role of DIS3L2 and oligouridylation as the cytoplasmic quality control for highly structured ncRNAs PMID: 27647875
Studies indicate important roles of the exoribonucleases DIS3L2 and XRN1 in cellular function, viability and disease. PMID: 27911720
these results indicate that catalytically inactive DIS3L2, characteristic of Perlman syndrome, can lead to deregulation of its target RNAs to disturb transcriptome homeostasis. PMID: 27431325
DIS3L2 interacts with Ago2 and governs target RNA-directed miRNA degradation. PMID: 26809675
DIS3L2 is the missing component of the LIN28-TUT4/7-DIS3L2 pathway required for the repression of let-7 in pluripotent cells. PMID: 24141620
in cellular models DIS3L2 knockdown is associated with abnormalities of cell growth and division PMID: 23613427
Germline mutations in DIS3L2 cause the Perlman syndrome of overgrowth and Wilms tumor susceptibility. PMID: 22306653

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Involvement in disease

Perlman syndrome (PRLMNS)

Subcellular Location

Cytoplasm. Cytoplasm, P-body.

Protein Families

RNR ribonuclease family, DIS3L2 subfamily

Database Links

HGNC: 28648

OMIM: 267000

KEGG: hsa:129563

STRING: 9606.ENSP00000315569

UniGene: Hs.732236

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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