DLX1 Antibody

Datasheet

Code	CSB-PA006952LA01HU
Size	US$166
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Image	Immunofluorescence staining of Hela cells with CSB-PA006952LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) DLX1 Polyclonal antibody

Uniprot No.

P56177

Target Names

DLX1

Alternative Names

DII B antibody; Distal less homeo box 1 antibody; Distal less homeobox 1 antibody; Distal-less homeobox gene 1a antibody; Dlx 1 antibody; Dlx antibody; Dlx1 antibody; Dlx1 distal-less homeobox 1 antibody; DLX1_HUMAN antibody; Homeo box protein DLX1 antibody; Homeobox protein DLX 1 antibody; Homeobox protein DLX-1 antibody; Homeobox protein Dlx1a antibody; Homeodomain transcription factor DLX1 antibody; MGC189409 antibody; OTTHUMP00000082494 antibody; OTTHUMP00000082497 antibody; OTTMUSP00000014202 antibody; RP23-419H3.3 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Homeobox protein DLX-1 protein (8-114AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The DLX1 Antibody (Product code: CSB-PA006952LA01HU) is Non-conjugated. For DLX1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA006952LB01HU	DLX1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA006952LC01HU	DLX1 Antibody, FITC conjugated
Biotin	CSB-PA006952LD01HU	DLX1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IF

Recommended Dilution

Application	Recommended Dilution
IF	1:50-1:200

Protocols

ELISA Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Plays a role as a transcriptional activator or repressor. Inhibits several cytokine signaling pathways, such as TGFB1, activin-A/INHBA and BMP4 by interfering with the transcriptional stimulatory activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3 during hematopoietic cell differentiation. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions.

Gene References into Functions

observations suggest that altered DLX1 methylation and expression contribute to pathogenesis of PSP by influencing MAPT. PMID: 30050033
Our results provided evidence that polymorphisms in TIMP1, DLX1 and DLX2 genes may be associated with DF phenotypes. PMID: 28131910
DLX1 mRNA levels were shown to be good predictors for the detection of High-grade Prostate Cancer. PMID: 27108162
these data strongly suggest that DLX1 has a pivotal role in FOXM1 signaling to promote cancer aggressiveness through intensifying TGF-beta/SMAD4 signaling in high-grade serous ovarian cancer cells. PMID: 27593933
TDT results showed an association between DLX1 and cleft lip and palate, in which the A allele was undertransmited (p=0.022). PMID: 25463899
The study data demonstrate an association between SNP rs7888172 of the DLX1 gene and non-syndromic hypodontia in Chinese Han individuals. PMID: 22984994
The regulation of fate switch between cortical and striatal interneurons is dependent on Dlx1 (and Dlx2). PMID: 23312518
These findings suggest that alterations in DLX1/2 contribute to the biological consequences of FLT3 activation. PMID: 21357706
DLX1 may function as a regulator of multiple signals from TGF-beta superfamily members in broad biological contexts during blood production PMID: 14671321
The DLX1 and DLX2 genes lie head-to-head in 2q32; the findings support the presence of two functional polymorphisms, one in or near each of the DLX genes that increase susceptibility to, or cause, autism. PMID: 18728693

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Subcellular Location

Nucleus.

Protein Families

Distal-less homeobox family

Tissue Specificity

Expressed in hematopoietic cell lines.

Database Links

HGNC: 2914

OMIM: 600029

KEGG: hsa:1745

STRING: 9606.ENSP00000354478

UniGene: Hs.407015

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Protein Service

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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