DNAJC2 Antibody

Datasheet

Code	CSB-PA858715ESR2HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA858715ESR2HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA858715ESR2HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) DNAJC2 Polyclonal antibody

Uniprot No.

Q99543

Target Names

DNAJC2

Alternative Names

AU020218 antibody; DnaJ (Hsp40) homolog subfamily C member 2 antibody; DnaJ homolog subfamily C member 2 antibody; Dnajc2 antibody; DNJC2_HUMAN antibody; M phase phosphoprotein 11 antibody; M-phase phosphoprotein 11 antibody; MGC105894 antibody; MIDA1 antibody; MPHOSPH11 antibody; MPP11 antibody; OTTMUSP00000031226 antibody; ZRF1 antibody; Zrf2 antibody; ZUO1 antibody; Zuotin related factor 1 antibody; Zuotin related factor 2 antibody; Zuotin-related factor 1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human DnaJ homolog subfamily C member 2 protein (1-140AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation.

Gene References into Functions

These findings suggest that ZRF1 plays a crucial role in tumor malignant potential through its overexpression and highlight its usefulness as a prognostic factor and potential therapeutic target in gastric cancer PMID: 29228320
Unexplored functions of ZRF1-mediated remodeling in replication and double strand break repair are discussed. PMID: 27599465
ZRF1 mediates remodeling of this E3 ligase complex directly at the DNA lesion site. PMID: 27091446
The antibody response to ZRF1 was higher in sera of patients with invasive ductal carcinoma than in sera of patients with other histological types of breast tumors. PMID: 27847402
Zrf1 is transcriptional regulator of neural fate downstream of Id1 in embryonic stem cells.During embryonic stem cell differentiation, Id1 levels decrease allowing Zrf1 to activate neural genes. PMID: 25361733
our data reveal that ZRF1 is a key transcriptional regulator in leukemia progression PMID: 24292673
Zrf1 plays an essential role in neural progenitor cell generation and maintenance PMID: 24449271
ZRF1 regulates the INK4-ARF locus during cellular proliferation and senescence, and alterations in ZRF1 may contribute to tumorigenesis. PMID: 22733129
the majority of AML patients elicited a humoral immune response against the tumor antigen MPP11 PMID: 22433847
describe a novel epitope derived from the MPP11 antigen that has been recognized by human CD8+ CTL PMID: 20231810
At the onset of differentiation, ZRF1 specifically displaces polycomb-repressive complex 1 (PRC1) from chromatin and facilitates transcriptional activation PMID: 21179169
concluded that Mpp11, an ortholog of yeast Zuo, is a ribosome-associated J protein; proposed that in metazoans, ribosome-associated Zuo and Mpp11 orthologs recruit cytosolic Hsc70 to short ribosome-bound nascent chains as they exit the ribosome PMID: 15802566
MPP11 is localized to the cytosol and with Hsp70L1, forms the mammalian ribosome-associated complex. PMID: 16002468

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Subcellular Location

Nucleus. Cytoplasm, cytosol.

Tissue Specificity

Widely expressed.

Database Links

HGNC: 13192

OMIM: 605502

KEGG: hsa:27000

STRING: 9606.ENSP00000368565

UniGene: Hs.558476

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Service

Phage Display Service

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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