DNTTIP1 Antibody, HRP conjugated

Code CSB-PA007089LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DNTTIP1 Polyclonal antibody
Uniprot No.
Target Names
DNTTIP1
Alternative Names
C20orf167 antibody; Deoxynucleotidyltransferase terminal interacting protein 1 antibody; Deoxynucleotidyltransferase terminal-interacting protein 1 antibody; dJ447F3.4 antibody; DNTTIP1 antibody; TdIF 1 antibody; TdIF1 antibody; TDIF1_HUMAN antibody; TdT binding protein antibody; TdT interacting factor 1 antibody; TdT-interacting factor 1 antibody; Terminal deoxynucleotidyltransferase interacting factor 1 antibody; Terminal deoxynucleotidyltransferase-interacting factor 1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Deoxynucleotidyltransferase terminal-interacting protein 1 protein (1-329AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA.
Gene References into Functions
  1. In luciferase assays, TdIF1 can up-regulate transcription activity of the promoters containing the TdIF1-binding sequences, and this effect is mainly through the palindrome 5'-TGCATG-3'. PMID: 25619743
  2. During cell division, DNTTIP1 is part of the mitotic deacetylase complex MIDAC, which also contains C14ORF43/MIDEAS and HDAC1/HDAC2. PMID: 21258344
  3. During cell division, DNTTIP1 forms a complex with C14ORF43/MIDEAS and HDAC1/HDAC2. PMID: 21258344
  4. The TdT binding, DNA binding and dimerization regions, and nuclear localization signal (NLS) in TdIF1, were identified. PMID: 17663723
Subcellular Location
Nucleus.
Database Links

HGNC: 16160

OMIM: 611388

KEGG: hsa:116092

STRING: 9606.ENSP00000361705

UniGene: Hs.472852

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