DOC2B Antibody

Datasheet

Code	CSB-PA618877LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA618877LA01HU at dilution of 1:100 Immunofluorescent analysis of HepG2 cells using CSB-PA618877LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) DOC2B Polyclonal antibody

Uniprot No.

Q14184

Target Names

DOC2B

Alternative Names

Doc2 beta antibody; Doc2-beta antibody; Doc2b antibody; DOC2B_HUMAN antibody; DOC2BL antibody; Double C2 like domain containing protein beta antibody; Double C2 like domains beta antibody; Double C2 like domains beta like antibody; Double C2-like domain-containing protein beta antibody; OTTMUSP00000006522 antibody; RP23 78H4.2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Double C2-like domain-containing protein beta protein (7-180AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The DOC2B Antibody (Product code: CSB-PA618877LA01HU) is Non-conjugated. For DOC2B Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA618877LB01HU	DOC2B Antibody, HRP conjugated	ELISA
FITC	CSB-PA618877LC01HU	DOC2B Antibody, FITC conjugated
Biotin	CSB-PA618877LD01HU	DOC2B Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes.

Gene References into Functions

Reduction of DOC2B is an early feature of T1 diabetes (T1D), and DOC2B abundance may serve as a valuable in vivo indicator of beta-cell mass and an early biomarker of T1D. PMID: 29506054
Here the authors report that analogous ring-like oligomers assemble from the C2AB domains of other Syt isoforms (Syt2, Syt7, Syt9) as well as related C2 domain containing protein, Doc2B and extended Synaptotagmins (E-Syts). PMID: 27434670
promoter hypermethylation and silencing of the DOC2B gene is an early and frequent event during cervical carcinogenesis and whose reduced expression due to DNA promoter methylation may lead to selective cervical tumor growth PMID: 24570007
Study analyzed Doc2alpha and Doc2beta and found that Doc2 responds to changes in [Ca2+], with markedly slower kinetics as compared to the cytosolic domain of syt I (syt), and operates on a timescale consistent with asynchronous neurotransmitter release. PMID: 22036572

Subcellular Location

Cytoplasm. Cytoplasmic granule. Cell membrane; Peripheral membrane protein.

Tissue Specificity

Widely expressed with highest levels in brain and kidney. Expressed in pancreatic islet cells (at protein level).

Database Links

HGNC: 2986

OMIM: 604568

KEGG: hsa:8447

STRING: 9606.ENSP00000343665

UniGene: Hs.551705

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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