DOCK10 Antibody, FITC conjugated

Code CSB-PA842645LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DOCK10 Polyclonal antibody
Uniprot No.
Target Names
DOCK10
Alternative Names
DOCK10 antibody; KIAA0694 antibody; ZIZ3Dedicator of cytokinesis protein 10 antibody; Zizimin-3 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Dedicator of cytokinesis protein 10 protein (1645-2186AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression.
Gene References into Functions
  1. T cells and B cells exhibited inverse expression patterns of the DOCK10 isoforms PMID: 21514340
  2. Dock10 could represent a point of convergence for interleukin 4 signalling and small Rho GTPase function in B cells. PMID: 18499258
  3. Silencing DOCK10 expression in melanoma promotes conversion to mesenchymal migration and is associated with decreased MLC2 phosphorylation and increased Rac1 activation. PMID: 18835169
Subcellular Location
Nucleus. Cytoplasm. Cell projection, dendritic spine.
Protein Families
DOCK family
Tissue Specificity
Expressed at low level in brain and lung. Isoform 1 is enriched in normal T-cells, isoform 3 is enriched in normal B-cells and chronic lymphocytic leukemia (CLL) B-cells.
Database Links

HGNC: 23479

OMIM: 611518

KEGG: hsa:55619

STRING: 9606.ENSP00000258390

UniGene: Hs.46578

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