DOK4 Antibody

Code CSB-PA007110GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
DOK4
Alternative Names
DOK4Docking protein 4 antibody; Downstream of tyrosine kinase 4 antibody; Insulin receptor substrate 5 antibody; IRS-5 antibody; IRS5 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human DOK4
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells.
Gene References into Functions
  1. the current study have explored in more detail the structure and function of the Dok-4 PTB domain. PMID: 22982678
  2. DOK4 expression in human T cells has been demonstrated, and its genomic structure has been predicted. PMID: 12595900
  3. IRS5/DOK4 and IRS6/DOK5 represent two new signaling proteins with potential roles in insulin and IGF-1 action PMID: 12730241
  4. Results suggest that Dok-4, through activation of the Rap1-ERK1/2 pathway, regulates GDNF-mediated neurite outgrowth during neuronal development. PMID: 16820412
  5. IRS-5 (DOK4) is significantly upregulated in 90% of examined clear cell RCCs. Studies on this gene has shown that it is regulated through chromatin remodeling in kidney cells PMID: 17443497
  6. Epigenetic regulation of DOK4 expression is associated with non-small-cell lung cancer. PMID: 19073520
  7. Dok-4 represents a novel negative regulator of T cells PMID: 19494292

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Protein Families
DOK family, Type B subfamily
Tissue Specificity
Widely expressed. High expression in skeletal muscle, heart, kidney and liver. Weaker expression in spleen, lung and small intestine, brain, heart and. Expressed in both resting and activated peripheral blood T-cells.
Database Links

HGNC: 19868

OMIM: 608333

KEGG: hsa:55715

STRING: 9606.ENSP00000344277

UniGene: Hs.279832

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