DPH3 Antibody, HRP conjugated

Code CSB-PA822214LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DPH3 Polyclonal antibody
Uniprot No.
Target Names
DPH3
Alternative Names
DPH3 antibody; DESR1 antibody; ZCSL2DPH3 homolog antibody; CSL-type zinc finger-containing protein 2 antibody; DelGEF-interacting protein 1 antibody; DelGIP1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human DPH3 homolog protein (1-82AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 (EEF2) and which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta).; Down-regulation increases extracellular release of proteoglycans, indicating a possible role in the secretion process. Stimulates binding of GNEFR to SEC5.
Gene References into Functions
  1. The results from this study show occurrence of frequent somatic non-coding mutations adjacent to a pre-existing binding site for Ets transcription factors within the directional promoter of DPH3 and OXNAD1 genes in three major skin cancers. PMID: 26416425
  2. DelGIP1is a binding partner of deafness locus putative guanine nucleotide exchange factor; downregulation of DelGIP1 induced increased extracellular secretion of proteoglycans indicating a possible role for DelGIP1 in the secretion process PMID: 14980502
  3. Solution structure of human DESR1, a CSL zinc-binding protein. PMID: 18214955
Subcellular Location
Cytoplasm. Nucleus.
Protein Families
DPH3 family
Tissue Specificity
Widely expressed with highest levels in small intestine, spleen, thymus, heart, liver and lung.
Database Links

HGNC: 27717

OMIM: 608959

KEGG: hsa:285381

STRING: 9606.ENSP00000419599

UniGene: Hs.388087

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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