DRAP1 Antibody, FITC conjugated

Datasheet

Code	CSB-PA05144C0Rb
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) DRAP1 Polyclonal antibody

Uniprot No.

Q14919

Target Names

DRAP1

Alternative Names

DR1 associated corepressor antibody; DR1 associated protein 1 (negative cofactor 2 alpha) antibody; DR1 associated protein 1 antibody; DR1 associated protein1 antibody; Dr1-associated corepressor antibody; Dr1-associated protein 1 antibody; DRAP 1 antibody; Drap1 antibody; NC 2 alpha antibody; NC 2alpha antibody; NC2 alpha antibody; NC2-alpha antibody; NC2A_HUMAN antibody; Negative co-factor 2-alpha antibody; Negative cofactor 2 alpha antibody; Negative cofactor 2alpha antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Dr1-associated corepressor protein (4-198AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own.

Gene References into Functions

Hypoxia actively represses transcription by inducing this protein and blocking preinitiation complex assembly. PMID: 12477712
physical cooperation between BTAF1 and NC2alpha in TBP regulation PMID: 15509807
The global distribution of DRAP1 on promoters was determined. PMID: 17548813
provide evidence that negative cofactor-2 (NC2) induces dynamic conformational changes in the TBP-DNA complex that allow it to escape and return to TATA-binding mode PMID: 17994103
heterodimerization with NC2alpha masks the nuclear localization signal in NC2beta, which prevents nuclear export of the NC2 complex PMID: 19204005

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Subcellular Location

Nucleus.

Protein Families

NC2 alpha/DRAP1 family

Tissue Specificity

Ubiquitous. Highly expressed in adult testis, heart, skeletal muscle, pancreas and brain, and in fetal brain, liver and kidney.

Database Links

HGNC: 3019

OMIM: 602289

KEGG: hsa:10589

STRING: 9606.ENSP00000307850

UniGene: Hs.356742

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Phage Display Service

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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