DRAP1 Antibody, FITC conjugated

Code CSB-PA05144C0Rb
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DRAP1 Polyclonal antibody
Uniprot No.
Target Names
DRAP1
Alternative Names
DR1 associated corepressor antibody; DR1 associated protein 1 (negative cofactor 2 alpha) antibody; DR1 associated protein 1 antibody; DR1 associated protein1 antibody; Dr1-associated corepressor antibody; Dr1-associated protein 1 antibody; DRAP 1 antibody; Drap1 antibody; NC 2 alpha antibody; NC 2alpha antibody; NC2 alpha antibody; NC2-alpha antibody; NC2A_HUMAN antibody; Negative co-factor 2-alpha antibody; Negative cofactor 2 alpha antibody; Negative cofactor 2alpha antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Dr1-associated corepressor protein (4-198AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own.
Gene References into Functions
  1. Hypoxia actively represses transcription by inducing this protein and blocking preinitiation complex assembly. PMID: 12477712
  2. physical cooperation between BTAF1 and NC2alpha in TBP regulation PMID: 15509807
  3. The global distribution of DRAP1 on promoters was determined. PMID: 17548813
  4. provide evidence that negative cofactor-2 (NC2) induces dynamic conformational changes in the TBP-DNA complex that allow it to escape and return to TATA-binding mode PMID: 17994103
  5. heterodimerization with NC2alpha masks the nuclear localization signal in NC2beta, which prevents nuclear export of the NC2 complex PMID: 19204005

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Subcellular Location
Nucleus.
Protein Families
NC2 alpha/DRAP1 family
Tissue Specificity
Ubiquitous. Highly expressed in adult testis, heart, skeletal muscle, pancreas and brain, and in fetal brain, liver and kidney.
Database Links

HGNC: 3019

OMIM: 602289

KEGG: hsa:10589

STRING: 9606.ENSP00000307850

UniGene: Hs.356742

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