DSC1 Antibody

1. DSC1 expression is significantly downregulated in human masticatory mucosa during wound healing PMID: 28005267
2. Increased expression of DSC1 can promote the occurrence of head and neck squamous cell carcinoma (HNSCC) and is associated with tumor. The increased expression of DSC1 also indicates a poor prognosis of the patients with HNSCC. PMID: 27601166
3. Low expression of DSC 1, 2, and 3 was observed in 55, 54, and 79 % of liver metastases. PMID: 23975055
4. High expression of desmocollin 1 (DSC1) was observed in 41.6%, DSC2 in 58.0%, DSC3 in 61.4%, E-cadherin in 71.4%, CDX2 in 58.0%, PITX1 in 55.0%, CDK4 in 0.2%, TLE1 in 1.3%, Factor H in 42.5%, and MDM2 in 0.2% of colorectal carcinomas. PMID: 22438068
5. The ultrastructural modifications of desmosomes during terminal differentiation of hair follicles are paralleled by the modulation of the synthesis of desmocollin 1. PMID: 15140019
6. in majority of patients with Netherton syndrome, Dsg1 & Dsc1 were reduced in living layers of epidermis; SCTE-like & SCCE-like activities were increased, suggesting these proteases participate in premature degradation of corneodesmosomal cadherins PMID: 16628198
7. Increased Dsc1 protein is associated with colorectal cancer PMID: 17088906

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HGNC: 3035

OMIM: 125643

KEGG: hsa:1823

STRING: 9606.ENSP00000257198

UniGene: Hs.567260