DSCAM Antibody, FITC conjugated

Code CSB-PA007192LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DSCAM Polyclonal antibody
Uniprot No.
Target Names
DSCAM
Alternative Names
CHD2 42 antibody; CHD2 52 antibody; CHD2 antibody; Down syndrome cell adhesion molecule antibody; DSCAM antibody; DSCAM_HUMAN antibody; human CHD2-52 down syndrome cell adhesion molecule 2; 9 antibody; OTTHUMP00000109193 2 antibody; SD11109p antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Down syndrome cell adhesion molecule protein (1711-1867AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies. Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. Might also collaborate with UNC5C in NTN1-mediated axon repulsion independently of DCC. In spinal cord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding. Enhances netrin-induced phosphorylation of PAK1 and FYN. Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38. Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions.
Gene References into Functions
  1. Our study did not repeatedly confirm the association of the rs2222973 or the rs11770843 SNP with adolescent idiopathic scoliosis in a Chinese Han population. PMID: 25408124
  2. The most significant was DSCAM, a neurological gene expressed widely in the developing brain and in the amygdala and hippocampus of the adult brain. PMID: 25867994
  3. DSCAM physically interacts with tubulin folding cofactor D. PMID: 25653356
  4. DSCAM as a Hirschsprung disease (HSCR) susceptibility locus, both in Down syndrome and HSCR isolated cases. PMID: 23671607
  5. Down syndrome cell adhesion molecule interacts with PRKAG1 subunit and plays an important role in netrin-1 induced neurite outgrowth. PMID: 23479427
  6. knockdown of DSCAM inhibits netrin-induced tyrosine phosphorylation of UNC5C and Fyn as well as the interaction of UNC5C with Fyn. The double knockdown of both receptors abolishes the induction of Fyn tyrosine phosphorylation by netrin-1 PMID: 22685302
  7. The specificity of Drosophila Dscam is due to complementarity of variable residues in epitope I. PMID: 17721508
  8. Overall, our study found a significant association of IL-17RC gene polymorphisms with AIS in a Chinese Han population, indicating IL-17RC gene may be as a susceptibility gene for AIS. PMID: 22744455
  9. Dscam may be involved in the generation and development of intractable epilepsy. PMID: 21360594
  10. functionally conserved with Drosophila Dscam[TM1] isoforms PMID: 21645617
  11. A specific promoter region directs expression of DSCAM in the developing choroid plexus and roof of the fourth ventricle, the floor plate of the fourth ventricle, pons and medulla oblongata, and the eye, limb buds, and dorsal root ganglion PMID: 12435380
  12. These results suggest the possible contribution of DSCAM gene in bipolar disorder. PMID: 18197079
  13. findings demonstrate an essential role of vertebrate DSCAM in axon guidance, indicating that DSCAM functions as a receptor of netrin-1 PMID: 19196994
  14. Dscam transgene with or without exon 19 in its endodomain is used to govern different stage-specific neuronal morphogenetic processes, possibly due to differences in protein targeting. PMID: 19211897
  15. In all transgenic retinal cell types examined, both DSCAM and DSCAM-LIKE1 genes are functioning similarly in self-avoidance, whereas the stratification of neurites and synaptic specificity are intact in their absence. PMID: 19945391

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Subcellular Location
[Isoform Short]: Secreted.; [Isoform Long]: Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite. Cell projection, growth cone. Cell junction, synapse.
Tissue Specificity
Primarily expressed in brain.
Database Links

HGNC: 3039

OMIM: 602523

KEGG: hsa:1826

STRING: 9606.ENSP00000383303

UniGene: Hs.160418

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