DUSP15 Antibody

Datasheet

Code	CSB-PA861994LA01HU
Size	US$166
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Image	IHC image of CSB-PA861994LA01HU diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. Immunofluorescence staining of A549 cells with CSB-PA861994LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) DUSP15 Polyclonal antibody

Uniprot No.

Q9H1R2

Target Names

DUSP15

Alternative Names

bA243J16.5 antibody; Chromosome 20 open reading frame 57 antibody; Dual specificity phosphatase 15 antibody; Dual specificity phosphatase like 15 antibody; Dual specificity protein phosphatase 15 antibody; DUS15_HUMAN antibody; DUSP15 antibody; EC 3.1.3.16 antibody; EC 3.1.3.48 antibody; FLJ20645 antibody; Vaccinia virus VH1 related dual specific protein phosphatase Y antibody; Vaccinia virus VH1-related dual-specific protein phosphatase Y antibody; VH1 related member Y antibody; VH1-related member Y antibody; VHY antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Dual specificity protein phosphatase 15 protein (1-295AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The DUSP15 Antibody (Product code: CSB-PA861994LA01HU) is Non-conjugated. For DUSP15 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA861994LB01HU	DUSP15 Antibody, HRP conjugated	ELISA
FITC	CSB-PA861994LC01HU	DUSP15 Antibody, FITC conjugated
Biotin	CSB-PA861994LD01HU	DUSP15 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6.; May play a role in the regulation of oligodendrocyte differentiation. May play a role in the regulation of myelin formation. Involved in the regulation of Erk1/2 phosphorylation in Schwann cells; the signaling may be linked to the regulation of myelination.

Gene References into Functions

The results showed that dual specificity phosphatase 15 (DUSP15) rs3746599 was significantly associated with autism under allelic, additive and dominant models,The findings initially suggest that DUSP15 might be a susceptibility gene for autism in Chinese Han population. PMID: 27223645
Dusp15/VHY is a key regulator of oligodendrocyte differentiation, and PDGFR-beta and SNX6 are novel and specific Dusp15 substrates. PMID: 22792334
VHY is a new member of a subgroup of myristoylated VH1-like small dual specificity phosphatases PMID: 15138252
crystal structure of catalytic domain PMID: 16170801

Subcellular Location

Cytoplasm.; [Isoform 3]: Cell membrane; Lipid-anchor; Cytoplasmic side.

Protein Families

Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily

Tissue Specificity

Highly expressed in testis. Expressed in brain; up-regulated in patients with multiple sclerosis gray matter lesions.

Database Links

HGNC: 16236

OMIM: 616776

KEGG: hsa:128853

STRING: 9606.ENSP00000341658

UniGene: Hs.434108

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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