DUSP5 Antibody

1. Methylation the DUSP5 gene promoter can serve as an additional means of identifying CIMP-high colorectal cancers. PMID: 29379130
2. DUSP5 expression in skeletal muscle was ninefold higher immediately after exercise and returned to pre-exercise level within 2 h. PMID: 28989118
3. Findings indicate that zinc-finger protein X-linked (ZFX) promotes colorectal cancer (CRC) progression by suppressing dual specificity phosphatase 5 (DUSP5) expression and suggest that ZFX is a prognostic biomarker and potentially useful therapeutic target in stage II/III CRC patients. PMID: 26967242
4. Results show that DUSP5 and DUSP6 mRNA are overexpressed in human PTCs, especially in BRAFV600E mutated papillary thyroid carcinomas (PTCs), and positively control cell migration and invasion. PMID: 28910386
5. role of the secondary binding site in assembling the DUSP5-pERK pre-reactive complex was further demonstrated by molecular dynamics simulations that showed that the remote C197-C219 disulfide linkage controls the structure of the secondary binding pocket based on its redox state (i.e., disulfide/dithiol) and, in turn, the enzymatic activity of DUSP5 PMID: 27739308
6. The DUSP5 S147P protein is hypoactive compared to the DUSP5 wild-type protein. PMID: 25519881
7. Data indicate that cells from Burkitt's lymphoma, leukemia, neuroblastoma and Ewing sarcoma showed a higher dual-specificity phosphatase 5 pseudogene 1 (DUSP5P1)/dual specificity phosphatase 5 (DUSP5 ratio than normal cells. PMID: 24651368
8. DUSP5 methylation may serve as a prognostic marker for gastric cancer (GC), but this requires validation in a larger set of GC samples. PMID: 23402999
9. Studies indicate that dual-specificity MAP kinase phosphatases (MKPs) DUSP6/MKP-3 and DUSP5 are localized in the cytoplasm and nuclear compartments. PMID: 22812510
10. DUSP5 and DUSP6 selectively control ERK pathway activity and proliferation. PMID: 20806045
11. the differential up-regulation of MKP3 by Ets2 and of DUSP5 by c-Jun may converge in similar functional roles for these MAP kinase phosphatases in the growth arrest versus proliferation decisions of breast cancer cells PMID: 20554528
12. In FD-Fms cells, overexpression of human DUSP5 increased M-CSF-dependent proliferation & decreased differentiation. Overexpression in multipotent EGER-Fms cells increased M-CSF-induced proliferation & caused granulocytic, not macrophage, differentiation. PMID: 19801501
13. DUSP5 is a direct target of p53. PMID: 12944906
14. DUSP5 inactivates ERK2 and causes both nuclear translocation and sequestration of inactive ERK2. PMID: 15713638
15. the crystal structure of the catalytic domain of DUSP5 in an active conformation. PMID: 17078075
16. proper regulation of DUSP5 activity is critical for normal immune system development, IL-2 actions, and tolerance PMID: 18430737
17. mutations in dusp-5 and snrk-1 have been identified in affected tissues of patients with vascular anomalies, implicating the Snrk-1-Dusp-5 signaling pathway in human disease. PMID: 18927432

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HGNC: 3071

OMIM: 603069

KEGG: hsa:1847

STRING: 9606.ENSP00000358596

UniGene: Hs.2128