DYNLRB1 Antibody, FITC conjugated

Datasheet

Code	CSB-PA865093HC01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) DYNLRB1 Polyclonal antibody

Uniprot No.

Q9NP97

Target Names

DYNLRB1

Alternative Names

DYNLRB1 antibody; BITH antibody; DNCL2A antibody; DNLC2A antibody; ROBLD1 antibody; HSPC162Dynein light chain roadblock-type 1 antibody; Bithoraxoid-like protein antibody; BLP antibody; Dynein light chain 2A antibody; cytoplasmic antibody; Dynein-associated protein Km23 antibody; Roadblock domain-containing protein 1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Dynein light chain roadblock-type 1 protein (3-96AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.

Gene References into Functions

Human colorectal carcinoma cells display decreased tumor progression and invasion when a novel anti-cell motility target, DYNLRB1, is being silenced. PMID: 23755307
TGFbeta regulates km23-1 interaction with the R1beta regulatory subunit of protein kinase A. PMID: 23333499
these findings demonstrate that km23-1 regulates RhoA and motility-associated actin modulating proteins, suggesting that km23-1 may represent a novel target for anti-metastatic therapy. PMID: 23079622
km23-1 is required for TGFbeta1 autoinduction through Smad2-independent Ras/ERK/JNK pathways PMID: 22637579
Silencing of km23, either through somatic genetic mutation or promoter hypermethylation, is rare in ovarian, breast, and colorectal cancers. PMID: 16778097
report the 2.1-A crystal structure of Dnlc2A using single anomalous diffraction PMID: 16970917
Infrequently mutated in human colorectal and gastric cancers. PMID: 17556076
DYNLRB1 specifically interacts with all three Rab6 isoforms and co-localises at the Golgi. PMID: 18044744
Identification of dynein light chain road block-1 as a novel interaction partner with the human reduced folate carrier. PMID: 19571232

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Subcellular Location

Cytoplasm, cytoskeleton.

Protein Families

GAMAD family

Tissue Specificity

High expression in heart, liver, brain and pancreas; moderate in placenta, skeletal muscle and kidney; low in lung, prostate, testis, small intestine and colon. Isoform 1 expression is up-regulated in 64% hepatocellular carcinoma (HCC) patients.

Database Links

HGNC: 15468

OMIM: 607167

KEGG: hsa:83658

STRING: 9606.ENSP00000349679

UniGene: Hs.593920

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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