Delta-ctenitoxin-Pn1a Antibody

Code CSB-PA349440HA01EUV
Size US$166
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Product Details

Uniprot No.
Alternative Names
antibody; Delta-ctenitoxin-Pn1a antibody; Delta-CNTX-Pn1a antibody; Insecticidal neurotoxin Tx4(6-1) antibody; PnTx4(6-1) antibody
Raised in
Rabbit
Species Reactivity
Phoneutria nigriventer
Immunogen
Recombinant Phoneutria nigriventer Delta-ctenitoxin-Pn1a protein (35-82AA)
Immunogen Species
Phoneutria nigriventer (Brazilian armed spider) (Ctenus nigriventer)
Conjugate
Non-conjugated

The Delta-ctenitoxin-Pn1a Antibody (Product code: CSB-PA349440HA01EUV) is Non-conjugated. For Delta-ctenitoxin-Pn1a Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA349440HB01EUV Delta-ctenitoxin-Pn1a Antibody, HRP conjugated ELISA
FITC CSB-PA349440HC01EUV Delta-ctenitoxin-Pn1a Antibody, FITC conjugated
Biotin CSB-PA349440HD01EUV Delta-ctenitoxin-Pn1a Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
This neurotoxin binds at site 3 of insect voltage-activated sodium channels (Nav) and prolongs evoked axonal action potentials by a slowing down of sodium current inactivation. The toxin also inhibits glutamate uptake from rat brain synaptosomes. It reversibly inhibits the N-methyl-D-aspartate (NMDA)-subtype of ionotropic glutamate receptor (GRIN). In addition, the toxin shows antinociceptive effect in all rat pain models tested (inflammatory, neuropathic and nociceptive). The antinociceptive effect is partially blocked when selective antagonists of both mu- and delta-opioid receptors are administered, revealing that the antinociceptive effect of the toxin involves both opiod and cannabinoid endogenous systems. In vivo, it is highly toxic to house fly (Musca domestica), toxic to cockroach, but has no effect when intracerebroventricularly injected into mice.
Subcellular Location
Secreted.
Protein Families
Spider toxin Tx2 family
Tissue Specificity
Expressed by the venom gland.
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