ECSCR Antibody, Biotin conjugated

1. Low expression level of ECSCR is associated with evasive resistance and disease progression in cancer. PMID: 26956051
2. identification of three novel full-length splice variants potentially encoding different protein isoforms PMID: 23147565
3. Endothelial cell-specific chemotaxis receptor (ECSCR) enhances vascular endothelial growth factor (VEGF) receptor-2/kinase insert domain receptor (KDR) activation and promotes proteolysis of internalized KDR. PMID: 23393131
4. ECSM2 modulated bFGF-directed endothelial cell motility via the FGF receptor (FGFR)-extracellular regulated kinase (ERK)-focal adhesion kinase (FAK) pathway. PMID: 21720547
5. Characterize a novel cell surface protein ECSM2 that regulates endothelial chemotaxis and tube formation, and interacts with filamin A. PMID: 18556573
6. ECSM2 is involved in cell-shape changes and actin cytoskeletal rearrangement, suppresses tyrosine phosphorylation signaling and ECSM2 can cross-talk with EGFR to attenuate the EGF-induced cell migration. PMID: 19267780
7. Knockdown of ARIA in HUVECs significantly reduced endothelial apoptosis without affecting either cell migration or proliferation. ARIA knockdown significantly increased inhibitor of apoptosis cIAP-1 and cIAP-2 protein expression PMID: 19416853
8. Observational study of gene-disease association. (HuGE Navigator) PMID: 19240791

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HGNC: 35454

KEGG: hsa:641700

UniGene: Hs.483538