Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) EFEMP2 Polyclonal antibody

Uniprot No.

O95967

Target Names

EFEMP2

Alternative Names

EFEMP 2 antibody; EFEMP2 antibody; EGF containing fibulin like extracellular matrix protein 2 antibody; EGF-containing fibulin-like extracellular matrix protein 2 antibody; FBLN 4 antibody; FBLN4 antibody; FBLN4_HUMAN antibody; FIBL 4 antibody; FIBL-4 antibody; FIBL4 antibody; Fibulin 4 antibody; Fibulin-4 antibody; MBP 1 antibody; MBP1 antibody; Mutant p53 binding protein 1 antibody; Protein UPH1 antibody; UPH 1 antibody; UPH1 antibody; UPH1 protein antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human EGF-containing fibulin-like extracellular matrix protein 2 protein (26-165AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Biotin

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Related Products

Target Background

Function

Plays a crucial role in elastic fiber formation in tissue, and in the formation of ultrastructural connections between elastic laminae and smooth muscle cells in the aorta, therefore participates in terminal differentiation and maturation of smooth muscle cell (SMC) and in the mechanical properties and wall integrity maintenance of the aorta. In addition, is involved in the control of collagen fibril assembly in tissue throught proteolytic activation of LOX leading to cross- linking of collagen and elastin. Also promotes ELN coacervation and participates in the deposition of ELN coacervates on to microfibrils but also regulates ELN cross- linking through LOX interaction. Moreover adheres to the cells through heparin binding in a calcium-dependent manner and regulates vascularlar smooth muscle cells proliferation through angiotensin signaling.

Gene References into Functions

different mutations in the fibulin-4 gene result in different molecular defects affecting secretion rates, protein stability, LOX-induced cross-linking, or binding to other ECM components and molecules of the TGF-beta pathway. PMID: 27339457
the expression of fibulin-4 was negatively correlated with the malignant phenotype of endometrial cancer cells. Fibulin-4 may have the ability to suppress endometrial cancer cell invasion and proliferation PMID: 28177909
The results revealed that fibulin-4 expression was upregulated in osteosarcoma, and was positively correlated with low differentiation, lymph node metastasis, and poor prognosis. Fibulin-4 was also found to be over-expressed in highly invasive cell lines and in the highly invasive subclones PMID: 28339091
Findings suggested that fibulin-4 is important for the proteolytic activation of lysyl oxidase which has a pivotal role in cross-linking of collagen and elastin. PMID: 26690653
Data indicates that Fibulin-4 is a novel gene that is found overexpressed in ovarian cancer and associated with poor prognostic clinicopathologic features. PMID: 25885889
pulmonary emphysema in aneurysmal Fibulin-4 deficient (Fibulin-4(R)) mice PMID: 25255451
Homozygous mutations in exon 7 of the FBLN4 gene can produce lethal vasculopathy. PMID: 24838734
This study demonstrated that fibulin-4 may serve as a new prognostic factor and as a potential therapeutic target for patients with cervical carcinoma. PMID: 24737201
The expression level of EFEMP2 is dramatically increased in colorectal cancer patients, even at the early stage, compared with healthy controls. PMID: 22506683
Studied Fibulin-4 expression in aortic wall to find out its role in aortic dissection development. Used samples of aortic wall from 10 patients operated for acute ascending aortic dissection and five patients for chronic ascending aortic dissection. PMID: 23518852
A lethal, genetic disorder characterized by severe deformation of elastic arteries, was linked to novel mutations in the FBLN4 gene. PMID: 22943132
Low EFEMP2 expression is associated with malignant pleural mesothelioma. PMID: 23313295
EFEMP2 is a novel PITX2-interacting protein that may bear importance for the development of anterior segment dysgenesis (ASD) and glaucoma. PMID: 22919265
FBLN4 has 10 coding exons PMID: 22070778
In this largest cohort of reported patients with a mutated EFEMP2 gene, we illustrate the phenotypic spectrum of inherited AA due to a novel EFEMP2 mutation. PMID: 22440127
patients with recessive FBLN4 mutations are predominantly characterized by aortic aneurysms, arterial tortuosity and stenosis; evidence for the involvement of altered TGFbeta signaling in the pathogenesis of FBLN4 mutations PMID: 20389311
Fibulin-4, expressed in chondrocytes and recognized as an autoantigen mainly in osteoarthritis (OA) rather than in rheumatoid arthritis, may play pathogenic roles in OA. PMID: 16493080
Fibulin-4, considered as a structural protein, may also participate in regulating elastic-fibre formation in human cells through the regulation of tropoelastin expression. PMID: 19627254