EIF4EBP3 Antibody

Code CSB-PA007565HA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA007565HA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA007565HA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) EIF4EBP3 Polyclonal antibody
Uniprot No.
Target Names
EIF4EBP3
Alternative Names
EIF4EBP3Eukaryotic translation initiation factor 4E-binding protein 3 antibody; 4E-BP3 antibody; eIF4E-binding protein 3 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Eukaryotic translation initiation factor 4E-binding protein 3 protein (1-100AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The EIF4EBP3 Antibody (Product code: CSB-PA007565HA01HU) is Non-conjugated. For EIF4EBP3 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA007565HB01HU EIF4EBP3 Antibody, HRP conjugated ELISA
FITC CSB-PA007565HC01HU EIF4EBP3 Antibody, FITC conjugated
Biotin CSB-PA007565HD01HU EIF4EBP3 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation.
Gene References into Functions
  1. Role of the eIF4EBP3 gene in miR-22-3p-mediated cervical squamous carcinoma cell growth PMID: 29333098
  2. The data reveal that 4E-BP3 expression is controlled by the transcription factor TFE3 through a cis-regulatory element in the EIF4EBP3 gene promoter. PMID: 27319316
  3. 4E-BP3 regulates eIF4E-mediated nuclear mRNA export and interacts with replication protein A2 PMID: 22684010
  4. potential prognostic factor for survival in patients with lung adenocarcinoma PMID: 20621385
  5. 4E-BP3 is associated with eIF4E in the cell nucleus and cytoplasm PMID: 12482586
  6. PHAS-II, but not PHAS-III, contributes to the control of protein synthesis by insulin PMID: 14507920
  7. there are overlapping reading frames in the mouse and human genes for 4E-BP3 and MASK PMID: 14557257

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Protein Families
EIF4E-binding protein family
Tissue Specificity
Expression is highest in skeletal muscle, heart, kidney, and pancreas, whereas there is very little expression in brain and thymus.
Database Links

HGNC: 3290

OMIM: 603483

KEGG: hsa:8637

STRING: 9606.ENSP00000308472

UniGene: Hs.594084

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