EIF4G2 Antibody, HRP conjugated

1. The percentage at the S-stage was decreased in the miR-379 mimics and EIF4G2 shRNA groups. PMID: 28381518
2. DAP5 knockdown from human ESCs (hESCs) resulted in persistence of pluripotent gene expression, delayed induction of differentiation-associated genes in different cell lineages, and defective embryoid body formation PMID: 27664238
3. Data show that microRNA miR-379 potentiated lung cancer (LCa) chemosensitivity via modulation of cisplatin (CDDP)-induced apoptosis by directly targeting the eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) 3' UTR. PMID: 28117895
4. These results indicate that miR-139 is capable of inhibiting chondrocyte proliferation and migration, thus being a possible therapeutic target for OA. The mechanism of miR-139 in chondrocytes may be related to its regulation on EIF4G2 and IGF1R. PMID: 27105918
5. The Coxsackievirus B3 protease 2A-mediated cleavage of DAP5 results in the production of two truncates that exert differential effects on protein translation of the IRES-containing genes, leading to enhanced host cell death. PMID: 26586572
6. Knockdown of EIF4G2 recapitulated the effects of mir-139, whereas restoring EIF4G2 expression rescued the mir-139 phenotype. elevated miR-139-5p expression is associated with a favorable outcome in acute myeloid leukemia. PMID: 26165837
7. findings provide the first mechanistic insights into the function of DAP5 as a selective regulator of cap-independent translation PMID: 25779044
8. Our results provide evidence that the tumor suppressor effect of miR-520c-3p is mediated through repression of translation while inducing senescence and that eIF4GII is a key effector of this anti-tumor activity. PMID: 24497838
9. DAP5, a translation initiation factor shown to positively regulate the translation of various internal ribosome entry sites containing mRNAs, promotes internal ribosome entry site-driven translation of p53 mRNA. PMID: 23318444
10. DAP5/p97 and DAP5/p86 enhanced the translation of the anti-apoptotic protein Bcl-2 and inhibited cisplatin-induced apoptosis PMID: 22555068
11. Multiple isoforms of eIF4GII arise from multiple promoters & alternative splicing events. A non-canonical CUG initiation codon extends the eIF4GII N-terminus. The eIF4GII N-terminus plays an alternative role in initiation factor assembly. PMID: 22909319
12. crystal structure of C-terminal region (residues 540-897) of p97/EIF4G2 (at 2.0 Angstrom resolution): sequence/structure homology with EIF4G1 PMID: 20544972
13. crystallization and preliminary X-ray diffraction analysis of the MIF4G domain of DAP5 is presented. PMID: 20057060
14. Includes the functional analysis of a similar protein in yeast. PMID: 11331597
15. The caspase-cleaved DAP5 protein supports internal ribosome entry site-mediated translation of death proteins PMID: 11943866
16. endogenous eIF4GII was phosphorylated by Ca(2+)/calmodulin-dependent protein kinase I PMID: 14507913
17. Cleavage of eIF4GII is induced in cells and in cell extracts by the FMDV leader protease (L(pro)) alone PMID: 15016848
18. EIF4G2 transcripts exhibited three different expression patterns, downregulation was found in about 50% of the cases analyzed and EIF4G2 gene transcription was associated with invasive tumors. PMID: 16410684
19. p97 is functionally different from the closely related C-terminal two-thirds of eIF4GI and it can positively promote protein synthesis and cell proliferation. PMID: 16932749
20. These data indicate that full-length p97 is a translational activator with essential role(s) in unstressed cells, suggesting a reassessment of current models of p97 function. PMID: 17237356
21. Data show that DAP5 promotes cap-independent translation of Bcl-2 and CDK1 to facilitate cell survival during mitosis. PMID: 18450493
22. role and regulation of death-associated protein-5 (DAP5/p97/NAT1), a novel inhibitor of translational initiation, in acute promyelocytic leukemia cell differentiation and apoptosis PMID: 18491231
23. Results report the crystal structure of the C-terminal region of DAP5/p97 extending between amino acids 730 and 897. PMID: 18722383
24. Exclusive use of a GUG translation initiation codon is conserved in human, chicken, Xenopus, and zebrafish. PMID: 15718103
25. translation starts exclusively at a non-AUG translation initiation codon (GUG). PMID: 9049310

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HGNC: 3297

OMIM: 602325

KEGG: hsa:1982

STRING: 9606.ENSP00000340281

UniGene: Hs.183684