EIF6 Antibody

1. in human CD4(+) T cells, eIF6 levels rapidly increase upon T-cell receptor activation and drive the glycolytic switch and the acquisition of effector functions PMID: 28743432
2. Studies indicate that eukaryotic translation initiation factor 6 (eIF6) is a central regulator of metabolism independent from mTOR protein and myc proto-oncogene protein (Myc). PMID: 27913676
3. Propose that eIF6 is necessary for malignant pleural mesothelioma growth. PMID: 26462016
4. EIF6 plays an important role in controlling cell motility and tumor metastasis. PMID: 25886394
5. eIF6 is a node regulator of ribosomal function and predict that prioritizing its pharmacological targeting will be of benefit in cancer and Shwachman-Bodian-Diamond syndrome PMID: 25252159
6. SBDS protein facilitates the release of eIF6, a factor that prevents ribosome joining. PMID: 23115272
7. eIF6 is one of the downstream effectors of Notch-1 in the pathway that controls cell motility and invasiveness in tumor cell lines PMID: 22348144
8. The interactions between P311 and ITGB4BP may be very important in the process of tumor cell differentiation and metastasis. PMID: 22365962
9. The benign prognosis of the Shwachman-Diamond syndrome patients with the int del (20)(q11.21q13.32) may be due to a gene/dosage effect for the EIF6 protein. PMID: 22295858
10. Inhibiting the induction of two proteins involved in two of the most significantly upregulated cellular processes, ribosome biogenesis (eIF6) and hnRNA splicing (SF3B2/SF3B4), showed that human T cells can enter the cell cycle without growing in size. PMID: 22415777
11. a direct role for SBDS and EFL1 in catalyzing the translational activation of ribosomes in all eukaryotes, and define SDS as a ribosomopathy caused by uncoupling GTP hydrolysis from eIF6 release PMID: 21536732
12. P311 and ITGB4BP expression was elevated in non-small cell lung cancer, possibly indicative of a new signaling pathway. PMID: 21029697
13. Ca(2+)-activated calcineurin phosphatase binds to and promotes nuclear localization of eIF6.Nuclear export of eIF6 is regulated by phosphorylation at Ser-174 and Ser-175 by the nuclear isoform of CK1. PMID: 21084295
14. eIF6 release regulates ribosome subunit joining and RACK1 provides a physical and functional link between PKC signalling and ribosome activation PMID: 14654845
15. ITGB4BP is overexpressed in head and neck cancers and its metastases. PMID: 15122657
16. Human eIF6 promoter contains consensus sites for the GABP (GA-binding protein) transcription factor complex. PMID: 16530192
17. results uncover an evolutionarily conserved function of the ribosome anti-association factor eIF6 in miRNA-mediated post-transcriptional silencing PMID: 17507929
18. Nuclear matrix proteins such as mutant Pyst1 and nucleophosmin 1 were downregulated, whereas eIF6 and beta-tubulin were upregulated during cell differentiation in hepatocarcinoma cells. PMID: 17569113
19. definitive evidence that eIF6 and dicer are both upregulated in a significant proportion of ovarian serous carcinomas PMID: 18327211

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HGNC: 6159

OMIM: 602912

KEGG: hsa:3692

STRING: 9606.ENSP00000363559

UniGene: Hs.743992